Synthesis of Gum Arabic-Based Biopolymer Network and Determination of Its Toxicity Properties in In Vitro - In Vivo Model Systems

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dc.contributor.authorAÇARI, İDİL KARACA
dc.contributor.authorTURHAN, DUYGU OZHAN
dc.contributor.authorKURUÇAY, Ali
dc.contributor.authorKoytepe, Suleyman
dc.contributor.authorAtes, Burhan
dc.date.accessioned2025-10-24T18:03:29Z
dc.date.available2025-10-24T18:03:29Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractIn this study, gum arabic based network polymers were prepared using epoxy functional PEG structures. The basic physicochemical properties of these structures, their structural characterization, thermal properties and morphological properties were investigated. Toxicity properties of constructs synthesized on zebrafish (Danio rerio (Hamilton)) offspring were determined in vivo. In addition, in vitro toxicity tests were performed on L929 fibroblast cells. When the general properties of these structures were examined. Structural and thermal properties were better with increasing cross-linker rates ratios (1%, 3%, 5%). According to the toxicity test performed on zebrafish juveniles; GA-PEG-Epox (1%) constructs are non-toxic to zebrafish juveniles. The mortality rate of GA-PEG-Epox (3%) and GA-PEG-Epox (5%) structures was observed as 12.5% and 20.8%, respectively. It was observed that the structures were not toxic to zebrafish juveniles. MTT test performed on L929 fibroblast cells, high cell viability (>90%) was observed in all synthesized structures. These results are evaluated as Grade 1 according to ISO standards.
dc.identifier.doi10.17776/csj.1385443
dc.identifier.endpage63
dc.identifier.issn2587-2680
dc.identifier.issn2587-246X
dc.identifier.issue1
dc.identifier.startpage54
dc.identifier.trdizinid1230141
dc.identifier.urihttps://doi.org/10.17776/csj.1385443
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1230141
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2272
dc.identifier.volume45
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofCumhuriyet Science Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subjectBiyoloji
dc.subjectBiyoteknoloji ve Uygulamalı Mikrobiyoloji
dc.subjectVeterinerlik
dc.subjectMalzeme Bilimleri
dc.subjectBiyomalzemeler
dc.subjectMTT
dc.subjectToxicity
dc.subjectBiopolymer network
dc.subjectGum arabic
dc.subjectZebrafish juveniles
dc.titleSynthesis of Gum Arabic-Based Biopolymer Network and Determination of Its Toxicity Properties in In Vitro - In Vivo Model Systems
dc.typeArticle

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