Protective Effect of Pomegranate Juice on Lead Acetate-Induced Liver Toxicity in Male Rats

Basit Öğe Kaydı
dc.contributor.authorPEKMEZ, HIDIR
dc.contributor.authorAnnaç, Ebru
dc.contributor.authorBulmus, Ozgur
dc.contributor.authorZencirci, Büşra
dc.contributor.authoraydın, merve
dc.contributor.authorAydın, Ali
dc.date.accessioned2025-10-24T18:04:19Z
dc.date.available2025-10-24T18:04:19Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: Lead has been reported to cause oxidative stress in liver tissues and cause histopathological changes. Studies have shown that pomegranate juice has antioxidant properties that prevent oxidative stress. In this study, the harmful effects of lead acetate on rat liver tissue and the efficacy of pomegranate juice against these effects were investigated. Methods: 28 male Wistar albino rats were divided into four groups: control, lead acetate (50 mL/ kg), pomegranate juice (1 mL/kg), and lead acetate + pomegranate juice (50 mL/kg+1 mL/kg). Lead acetate and pomegranate juice were administered orally. Results: When compared with the control group, it was seen that the lead acetate had an increase in the malondialdehyde level and a decrease in reduced Glutathione, Glutathione S-transferase, and Carboxylesterases. Group lead acetate + pomegranate juice had a reduction in malondialdehyde level and an increase in Glutathione, Glutathione S-transferase, and Carboxylesterases compared with the group lead acetate. The lead level of group lead acetate + pomegranate juice decreased compared to the group lead acetate. Cellular degeneration and irregular hepatic cords were observed in group lead acetate’s liver tissue, and the negative changes were lost in group lead acetate + pomegranate juice. Conclusion: It was observed that pomegranate juice had a protective effect against liver toxicity caused by lead acetate.
dc.identifier.doi10.58600/eurjther1927
dc.identifier.endpage169
dc.identifier.issn2564-7784
dc.identifier.issn2564-7040
dc.identifier.issue2
dc.identifier.startpage160
dc.identifier.trdizinid1235339
dc.identifier.urihttps://doi.org/10.58600/eurjther1927
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1235339
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2795
dc.identifier.volume30
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofEuropean Journal of Therapeutics
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subjectBiyoloji
dc.subjectKimya
dc.subjectAnalitik
dc.subjectÇevre Bilimleri
dc.subjectAntioxidant
dc.subjectOxidative stress
dc.subjectLiver
dc.subjectLead acetate
dc.subjectPomegranate juice
dc.titleProtective Effect of Pomegranate Juice on Lead Acetate-Induced Liver Toxicity in Male Rats
dc.typeArticle

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu