The effect of combined treatment of alpha-tocopherol, ascorbic acid, and pyridoxine with NMDA blocker memantine on penicillin-induced epileptiform activity in rats

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dc.authoridYildirim, Mehmet/0000-0003-1798-5478|AYYILDIZ, Mustafa/0000-0002-6594-3080;
dc.contributor.authorAydin, Duygu
dc.contributor.authorYildirim, Mehmet
dc.contributor.authorAyyildiz, Mustafa
dc.contributor.authorAgar, Erdal
dc.date.accessioned2025-10-24T18:09:49Z
dc.date.available2025-10-24T18:09:49Z
dc.date.issued2013
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAim: To evaluate the effects of coadministration of vitamins alpha-tocopherol, ascorbic acid, and pyridoxine with memantine on a penicillin-induced experimental epilepsy model in rats so as to clarify the eventual interaction between these vitamins and the N-methyl-D-aspartate (NMDA) system. Materials and methods: The epileptic focus was produced by intracortical penicillin G potassium injection. The effects of intraperitoneal injections of memantine, memantine + alpha-tocopherol, memantine + ascorbic acid, and memantine + pyridoxine combinations on epileptiform activity were evaluated in electrocorticogram recordings. Results: The antiepileptiform effects appeared earlier in all memantine and vitamin coadministrated groups compared to the memantine-alone group, but the difference between the groups was not statistically significant considering the frequency and amplitude of the epileptiform activity. Conclusion: Coadministration of vitamins does not enhance the antiepileptiform activity of memantine in penicillin-induced epilepsy in rats. However, this coadministration causes the earlier appearance of antiseizure effects. Since moderate doses of these vitamins have no side effects, it might be a good idea to use them with NMDA blockers to provide an earlier antiepileptic effect.
dc.identifier.doi10.3906/sag-1204-7
dc.identifier.endpage250
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2
dc.identifier.scopus2-s2.0-84875065735
dc.identifier.scopusqualityQ1
dc.identifier.startpage245
dc.identifier.trdizinid211642
dc.identifier.urihttps://doi.org/10.3906/sag-1204-7
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/211642
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3849
dc.identifier.volume43
dc.identifier.wosWOS:000321227500011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectExperimental epilepsy; NMDA; memantine; ascorbic acid; pyridoxine; alpha-tocopherol
dc.titleThe effect of combined treatment of alpha-tocopherol, ascorbic acid, and pyridoxine with NMDA blocker memantine on penicillin-induced epileptiform activity in rats
dc.typeArticle

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