Development of lidocaine-containing modified pleural talc structures as antibacterial drug delivery systems to prevent pleural effusion or pneumothorax

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dc.contributor.authorOzhan, Onural
dc.contributor.authorKoytepe, Suleyman
dc.contributor.authorAtes, Burhan
dc.contributor.authorAcari, Idil Karaca
dc.contributor.authorGurses, Canbolat
dc.contributor.authorParlakpinar, Hakan
dc.date.accessioned2026-06-19T06:41:15Z
dc.date.available2026-06-19T06:41:15Z
dc.date.issued2025
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPleurodesis is a common practice to close the pleural space and to treat persistent pneumothorax to prevent recurrent pleural effusion. When the patient has pleurodesis, the pleural fluid is drained first and then talc is applied to the pleural space. The talc application process consists of directly depositing the talc structure with the appropriate particle size into the relevant space. Both the space is filled and the patient's lung movement comfort is provided during the breathing process due to the slippery effect of the talc structure. Otherwise, the patient experiences a very painful process during the breathing process. However, some important indications can be observed both during and after the talc deposition. At the beginning of these indications is the formation of infection and innovative practices are very significant in eliminating such an infection. In order to prevent infection during talc process, intensive antibiotic application is made before and after the application. In this study, more effective and innovative talc structures were developed and the talc structure was modified with a zwitter ionic polymeric coating to prevent infection. A surface modification was carried out by attaching 3-vinylpropyl-triethoxysilane binding agent on the appropriately sized talc structures. The functionalized talc structure was transformed into a surface that would work with the kill and release principle. The structure of 2-(tert-butylamino)ethyl methacrylate was modified for this process. A quaternary ammonium structure was formed on the talc surface thereby, bacteria will be killed and then, removed from the surface. In the research, local anesthesic agent lidocaine was also loaded to provide convenience to the patient. Structural characterizations of the obtained structures were performed by Fourier Transform Infrared Spectrophotometer (FTIR). Its thermal properties were determined by thermogravimetric analysis (TGA), differential thermal analysis (DTA) and differential scanning calorimetry (DSC) techniques. Moreover, the antibacterial properties of the obtained structures were examined.
dc.description.sponsorshipIdot;nn University Scientific Research Project Unit [TCD-2020-2335]
dc.description.sponsorshipThe authors thank the financial support from the & Idot;nonu University Scientific Research Project Unit by Grant BAP (TCD-2020-2335).
dc.identifier.doi10.1007/s00289-025-06063-0
dc.identifier.issn0170-0839
dc.identifier.issn1436-2449
dc.identifier.issue1
dc.identifier.orcid0000-0001-9497-3468
dc.identifier.orcid0000-0001-6783-7030
dc.identifier.orcid0000-0001-9018-7849
dc.identifier.orcid0000-0002-4788-278X
dc.identifier.orcid0000-0002-4085-0224
dc.identifier.orcid0000-0001-6080-229X
dc.identifier.scopus2-s2.0-105023500779
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s00289-025-06063-0
dc.identifier.urihttps://hdl.handle.net/20.500.12899/6147
dc.identifier.volume83
dc.identifier.wosWOS:001631051300004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPolymer Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260612
dc.subjectPleural Talc
dc.subjectSurface Modification
dc.subjectAntibacterial Surfaces
dc.subjectKill And Release System
dc.subjectLidocaine
dc.titleDevelopment of lidocaine-containing modified pleural talc structures as antibacterial drug delivery systems to prevent pleural effusion or pneumothorax
dc.typeArticle

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