Leukocyte albumin ratio as an early predictor of mortality in critical COVID-19 patients

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dc.contributor.authorIn, E
dc.contributor.authorBerber, Nurcan Kırıcı
dc.contributor.authorKasapoğlu, Umut Sabri
dc.contributor.authorKarabulut, Ercan
dc.contributor.authorOzdemir, C
dc.contributor.authorAltıntop Geçkil, Ayşegül
dc.date.accessioned2022-03-08T13:18:30Z
dc.date.available2022-03-08T13:18:30Z
dc.date.issued2022en_US
dc.departmentMTÖ Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: The aim of this study is to analyze the effectiveness of the leukocyte albumin ratio (LAR) in predicting mortality in critical COVID-19 patients. Material and Methods: In this retrospectively-designed study, we evaluated a total of 98 critical patients who were hospitalized in the intensive care unit. Patients were divided into two groups according to hospital mortality as survivors (n=43) and non-survivors (n=55). Results: The non-survivors group was statistically significantly older (67.3 +/- 9.7 versus 62.5 +/- 10.9; p=0.023). HT and DM were detected more in the non-survivors group than in the survivors group (p=0.031, p=0.018, respectively). Mean LAR values were significantly higher in non-survivors than in survivors (5.9 +/- 3.5 versus 3.3 +/- 1.4; p<0.001). LAR values was positively correlated with urea (r=0.43, p<0.001), LDH (r=0.35, p<0.001), ferritin (r=0.25, p=0.015), procalcitonin (r=0.34, p<0.001), and pro-BNP (r=0.24, p=0.015) levels. A cut-off value of 3.71 ng/mL for LAR predicted mortality with a sensitivity of 76% and a specificity of 70% (AUC:0.779 95% Cl:0.689-0.870; p<0.001). Multivariable logistic regression analysis revealed that older age (OR:1.114, 95% CI:1.020-1.218; p=0.017) and increased ferritin (OR:1.003, 95% CI:1.001-1.004; p=0.002) and LAR (OR:1.583, 95% CI:1.073-2.337; p=0.021) values were independent predictors of mortality in patients with critical COVID-19. Discussion: LAR can be a useful and prognostic marker that can be used to predict mortality in COVID-19 patients admitted to the intensive care unit.en_US
dc.identifier.citationGeckil, A. A., In, E., Berber, N. K., Kasapoglu, U. S., Karabulut, E., & Ozdemir, C. (2021). Leukocyte albumin ratio as an early predictor of mortality in critical COVID-19 patients. Annals of Clinical and Analytical Medicine, 5-5.en_US
dc.identifier.doi10.4328/ACAM.20895
dc.identifier.endpage165en_US
dc.identifier.issn2667-663Xen_US
dc.identifier.issue2en_US
dc.identifier.startpage161en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12899/557
dc.identifier.volume13en_US
dc.language.isoenen_US
dc.publisherBayrakol Medıcal Publisheren_US
dc.relation.ispartofANNALS OF CLINICAL AND ANALYTICAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCOVID-19en_US
dc.subjectLeukocyte Albuminen_US
dc.subjectRatioIntensive Careen_US
dc.titleLeukocyte albumin ratio as an early predictor of mortality in critical COVID-19 patientsen_US
dc.typeArticleen_US

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