Preparation, characterization, and biocompatibility of chondroitin sulfate-based sol-gel coatings and investigation of their effects on osseointegration improvement

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dc.authoridSevimli, Doc. Dr. Resit/0000-0002-5394-9100|SEZER, Selda/0000-0002-3136-1250|Unver, Tuba/0000-0002-8655-2716|PASAHAN, Aziz/0000-0002-0657-3884|Ates, Burhan/0000-0001-6080-229X
dc.contributor.authorPasahan, Aziz
dc.contributor.authorSevimli, Resit
dc.contributor.authorKivilcim, Nilufer
dc.contributor.authorAcari, Idil Karaca
dc.contributor.authorErenler, A. Sebnem
dc.contributor.authorSezer, Selda
dc.contributor.authorDurmat, H. Turgut
dc.date.accessioned2025-10-24T18:09:13Z
dc.date.available2025-10-24T18:09:13Z
dc.date.issued2023
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractIn this work, implants with enhanced antibacterial and surface properties besides mechanical, biological, and chemical properties were prepared with the replacement of traditional titanium and titanium alloys in the field of biomedical materials. Titanium substrates were coated with chondroitin sulfate (CS) containing (3-glycidoxypropyl)trimethoxysilane (GLYMO) and tetraethoxysilane (TEOS) based thin film using sol-gel technology. Chondroitin sulfate is a preferred material due to its characteristics antioxidative and osseointegresion properties besides its collagen-forming properties. Coated implants were morphologically elucidated with atomic force microscopy (AFM), and scanning electron microscopy (SEM). The structure of the chondroitin sulfate-containing films was investigated with Fourier Transform Infrared Spectroscopy (FTIR) and Energy Dispersive X-Ray Analysis (EDX) techniques. The obtained CS-based sol-gel surface coatings are thermally stable up to similar to 200 degrees C according to TGA and DTA analysis results. The biological and antibacterial properties of the coatings were also determined. The biocompatibility and osseointegration properties of the coatings developed within the scope of the study were, determined by in vivo studies on rats. According to biocompatibility results of CS/Sol-Gel coated surfaces, Cell viability (%) rates of CS-based coatings showed between 89 and 66%. According to the experimental data, it has been claimed that implants improved with antibacterial, stable, homogeneous, and biocompatible coatings can be used as a new alternative product for dental and orthopedic applications.
dc.description.sponsorshipInonu University Research Fund [FOA2018-1325]
dc.description.sponsorshipWe gratefully to Inonu University Research Fund (Project No: FOA2018-1325).
dc.identifier.doi10.1080/00914037.2022.2105332
dc.identifier.endpage1528
dc.identifier.issn0091-4037
dc.identifier.issn1563-535X
dc.identifier.issue18
dc.identifier.startpage1510
dc.identifier.urihttps://doi.org/10.1080/00914037.2022.2105332
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3533
dc.identifier.volume72
dc.identifier.wosWOS:000832930300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherTaylor & Francis As
dc.relation.ispartofInternational Journal Of Polymeric Materials And Polymeric Biomaterials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectAntibacterial property; chondroitin sulfate; metallic implant; sol-gel chemistry
dc.titlePreparation, characterization, and biocompatibility of chondroitin sulfate-based sol-gel coatings and investigation of their effects on osseointegration improvement
dc.typeArticle

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