The effect of coasting on intracytoplasmic sperm injection outcome in antagonist and agonist cycle

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dc.contributor.authorIltemir Duvan, Zehra Candan
dc.contributor.authorNamlı Kalem, Muberra
dc.contributor.authorOnaran, Yüksel Arikan
dc.contributor.authorKeskin, Esra Aktepe
dc.contributor.authorAyrim, Aylin
dc.contributor.authorPekel, Aslihan
dc.contributor.authorKafali, Hasan
dc.date.accessioned2025-10-24T18:06:53Z
dc.date.available2025-10-24T18:06:53Z
dc.date.issued2017
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground: Coasting can reduce the ovarian hyperstimulation syndrome (OHSS) risk in ovulation induction cycles before intracytoplasmic sperm injection (ICSI). This study aimed to investigate the effect of gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist protocols to controlled ovarian hyperstimulation (COH) cycles with coasting on the parameters of ICSI cycles and the outcome. Materials and Methods: In a retrospective cohort study, 117 ICSI cycles were performed and coasting was applied due to hyperresponse, between 2006 and 2011. The ICSI outcomes after coasting were then compared between the GnRH agonist group (n=91) and the GnRH antagonist group (n=26). Results: The duration of induction and the total consumption of gonadotropins were found to be similar. Estradiol (E<inf>2</inf>) levels on human chorionic gonadotropin (hCG) day were found higher in the agonist group. Coasting days were similar when the two groups were compared. The number of mature oocytes and the fertilization rates were similar in both groups; however, the number of grade 1 (G1) embryos and the number of transferred embryos were higher in the agonist group. Implantation rates were significantly higher in the antagonist group compared to the agonist group. Pregnancy rates/embryo transfer rates were higher in the antagonist group; however, this difference was not statistically significant (32.8% for agonist group vs. 39.1% for antagonist group, P>0.05). Conclusion: The present study showed that applying GnRH-agonist and GnRH-antagonist protocols to coasted cycles did not result in any differences in cycle parameters and clinical pregnancy rates. © 2017 Elsevier B.V., All rights reserved.
dc.identifier.endpage6
dc.identifier.issn2008-076X
dc.identifier.issn2008-0778
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85008174086
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3266
dc.identifier.volume11
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherRoyan Institute (ACECR) info@celljournal.org
dc.relation.ispartofInternational Journal of Fertility and Sterility
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzScopus_20251023
dc.subjectGnRH agonist
dc.subjectGnRH antagonist
dc.subjectOvarian hyperstimulation syndrome
dc.titleThe effect of coasting on intracytoplasmic sperm injection outcome in antagonist and agonist cycle
dc.typeArticle

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