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    Effect of carnosine on ovarian follicle in rats exposed to electromagnetic field
    (Soc Anatomica Espanola, 2022) Arslan, Ayla; Balcioglu, Esra; Nisari, Mehtap; Yalcin, Betul; Ulger, Menekse; Guler, Emel; Uzun, Gokce Bagci
    The electromagnetic field (EMF) has an effect on various organs, including the female reproductive system. The purpose of this study was to evaluate the impact of carnosine on ovarian follicle number and diameter in rats exposed to a 900 Megahertz (Mhz) electromagnetic field. In this study, six different groups were used. 40 female rats divided into groups were evaluated. The ovaries of the rats were removed at the end of the study. Routine histological procedures were performed on ovarian tissues. Follicle number and diameter of all groups were calculated and evaluated under the light microscope. When primary follicle number and diameters were compared statistically among the groups, there was a remarkably meaningful difference between the EMF group and the control, 20 mg carnosine and EMF+20 mg carnosine groups (p<0.05). There were significant irregularities in the structure of the oocyte and the granulosa cells surrounding the oocyte, especially in the EMF-treated groups. However, the structure of the oocyte and the granulosa cells surrounding the oocyte in the EMF+20 mg carnosine group showed a more regular structure compared to the EMF group. In this study, it can be concluded that the number and diameter of ovarian follicles decreased in rats exposed to electromagnetic field and 20 mg of carnosine may prevent damage caused by EMF.
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    N-Acetyl Cysteine Reduces Cisplatin Ototoxicity
    (Aves, 2016) Somdas, Mehmet Akif; Gunturk, Inayet; Avci, Deniz; Yazici, Cevat; Balcioglu, Esra; Unsal, Selim; Gunduz, Mehmet
    Objective: To investigate the changes in otoacoustic emissions (OAEs) for detecting the ototoxicity of cisplatin and to study the possible preventive effect of N-acetylcysteine (NAC) in cisplatin ototoxicity. Materials and Methods: This study was conducted on 21 Wistar albino rats in four groups. Cisplatin, cisplatin plus NAC, NAC alone, and saline were intraperitoneally administered. The rats were anesthetized to study the otoacoustic emissions before and after the experiment. Results: The OAEs were attenuated in the cisplatin group: (-1.31/-4.90), (6.28/4.58), (4.00/0.93), (2.73/-3.74), (2.66/-4.53). The group that received NAC in addition to cisplatin had better OAEs. Conclusion: Cisplatin ototoxicity can be detected by OAE testing in rats, and NAC may reduce the ototoxic effect.