N-Acetyl Cysteine Reduces Cisplatin Ototoxicity
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Aves
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: To investigate the changes in otoacoustic emissions (OAEs) for detecting the ototoxicity of cisplatin and to study the possible preventive effect of N-acetylcysteine (NAC) in cisplatin ototoxicity. Materials and Methods: This study was conducted on 21 Wistar albino rats in four groups. Cisplatin, cisplatin plus NAC, NAC alone, and saline were intraperitoneally administered. The rats were anesthetized to study the otoacoustic emissions before and after the experiment. Results: The OAEs were attenuated in the cisplatin group: (-1.31/-4.90), (6.28/4.58), (4.00/0.93), (2.73/-3.74), (2.66/-4.53). The group that received NAC in addition to cisplatin had better OAEs. Conclusion: Cisplatin ototoxicity can be detected by OAE testing in rats, and NAC may reduce the ototoxic effect.
Açıklama
Anahtar Kelimeler
Ototoxicity; cisplatin; NAC; N-acetylcysteine; hearing
Kaynak
Erciyes Medical Journal
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
38
Sayı
3
