N-Acetyl Cysteine Reduces Cisplatin Ototoxicity

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dc.authoridYAZICI, Cevat/0000-0003-0625-9542|AVCI, DENIZ/0000-0003-2174-8379;
dc.contributor.authorSomdas, Mehmet Akif
dc.contributor.authorGunturk, Inayet
dc.contributor.authorAvci, Deniz
dc.contributor.authorYazici, Cevat
dc.contributor.authorBalcioglu, Esra
dc.contributor.authorUnsal, Selim
dc.contributor.authorGunduz, Mehmet
dc.date.accessioned2025-10-24T18:10:05Z
dc.date.available2025-10-24T18:10:05Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: To investigate the changes in otoacoustic emissions (OAEs) for detecting the ototoxicity of cisplatin and to study the possible preventive effect of N-acetylcysteine (NAC) in cisplatin ototoxicity. Materials and Methods: This study was conducted on 21 Wistar albino rats in four groups. Cisplatin, cisplatin plus NAC, NAC alone, and saline were intraperitoneally administered. The rats were anesthetized to study the otoacoustic emissions before and after the experiment. Results: The OAEs were attenuated in the cisplatin group: (-1.31/-4.90), (6.28/4.58), (4.00/0.93), (2.73/-3.74), (2.66/-4.53). The group that received NAC in addition to cisplatin had better OAEs. Conclusion: Cisplatin ototoxicity can be detected by OAE testing in rats, and NAC may reduce the ototoxic effect.
dc.description.sponsorshipDEKAM of Erciyes University; Erciyes University
dc.description.sponsorshipThis study was conducted thus supported by DEKAM of Erciyes University, partly supported by Funds of Erciyes University.
dc.identifier.doi10.5152/etd.2016.0068
dc.identifier.endpage114
dc.identifier.issn2149-2247
dc.identifier.issn2149-2549
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85015837903
dc.identifier.scopusqualityN/A
dc.identifier.startpage111
dc.identifier.trdizinid205078
dc.identifier.urihttps://doi.org/10.5152/etd.2016.0068
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/205078
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3975
dc.identifier.volume38
dc.identifier.wosWOS:000386676300005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-
dc.language.isoen
dc.publisherAves
dc.relation.ispartofErciyes Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectOtotoxicity; cisplatin; NAC; N-acetylcysteine; hearing
dc.titleN-Acetyl Cysteine Reduces Cisplatin Ototoxicity
dc.typeArticle

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