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Öğe A current method in gynecological cancer prediction: "Micronucleus": Review(OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S. aysea@turkiyeklinikleri.com Turkocagi Caddesi No. 30 Balgat 06520, 2016) Eser, Ayla Açar; Gürbüz, Neslihan; Kaygusuz, İkbal Cekmen; Canbal, Metin; Koş???us, Aydin; Köşüş, NerminPrediction and early diagnosis of cancer are vital in gynecology. Studies have shown that both micronucleus (MN) and micronucleus tests (MNT)s can be used to predict cancers. Approximately 92% of all of the human malignancies occur in epithelial tissues. The MN assay in exfoliated cells is an innovative genotoxicity technique which holds promise for the study of epithelial carcinogens. Micronuclei are usually produced during the metaphase/anaphase transition of mitosis. If the process of cell division is disturbed, the sharing of the genetic material to the two daughter nuclei may be affected. The same situation will also occur if the chromosomes are broken or damaged by radiation, drugs and chemicals. Under these conditions, the genetic materials that are not included in the nuclei of the daughter cells will then form its own "micronucleus". A MNT is a special toxicological test that is usually employed in screening chemical compounds that are potentially genotoxic. The main objective of the test is to identify those genotoxic agents, which are capable of modifying the structure and segregation of chromosomes, in a specific way that enables the induction of micronuclei in interphase cells. MNT is used to determine carcinogenic agents that are capable of triggering off a specific type of cytogenetic damage, which lead to the formation of micronuclei containing lagging chromosome fragments or whole chromosomes. Recently MNT began to be used in gynecology and will be one of the most important parameter in prediction, prognoses and response to treatment of cancer in the near future. © 2018 Elsevier B.V., All rights reserved.Öğe A potential association between the number of CA repeats in the promoter region of the ADAMTS9 gene with lymphatic metastasis of breast cancer(Tubitak Scientific & Technological Research Council Turkey, 2013) Bozer, Mikdat; Asik, Fatma; Acar, Muradiye; Haltas, Hacer; Yenidunya, Sibel; Canbal, Metin; Topcu, VehapAim: We investigated the effect of the number of cytosine-adenine (CA) repeats in the ADAMTS9 promoter region on breast cancer lymphatic metastasis. Materials and methods: Thirty-one postoperative breast cancer patients were selected and examined retrospectively. The patients were classified into 2 groups: metastatic or nonmetastatic. Thirty healthy women were selected as the control group, and their peripheral blood was obtained. Following DNA isolation from the cancer tissue specimens and peripheral blood, the promoter region of the ADAMTS9 gene was directly sequenced and the number of CA repeats was determined. Results: The number of CA repeats ranged between 19 and 21 in the control and metastatic groups. However, in the nonmetastatic group, the number of CA repeats ranged between 17 and 18. This difference in the median number of CA repeats between the control group and the nonmetastatic group was statistically significant. Conclusion: A potential relationship may exist between lymphatic metastasis in breast cancer and the number of CA repeats in the promoter region of the ADAMTS9 gene. Our study indicates a potential association between the number of CA microsatellite repeats in the promoter region of the ADAMTS9 gene and breast cancer lymphatic metastasis.Öğe Attitudes towards influenza vaccination in high socioeconomic status Turkish parents(Tubitak Scientific & Technological Research Council Turkey, 2014) Gunduz, Suzan; Yuksel, Cigdem Nuket; Aktoprak, Hale Bozkurt; Canbal, Metin; Kaya, MehmetBackground/aim: To better understand the knowledge, attitudes, and demographic factors that influence the rate of influenza vaccination among high socioeconomic status parents. Materials and methods: questionnaire exploring the attitudes of parents to the influenza vaccine, and their knowledge about influenza and its vaccination, was given to parents of children from 1 through 16 years of age attending the Turgut Ozal University Hospital after the 2011/12 influenza season. Results: In the present study, 285 mothers and their children participated and 8.8% (n = 25) of children had the influenza vaccination. Between the vaccinated and nonvaccinated groups, there were statistically significantly differences for having received the recommendation of the physician, consulting with the physician, having the influenza vaccine previously, and having a chronic disease. The most common misconceptions of the parents about the vaccine were; there being no need for it, it not being useful, it having no effect, and it being harmful. Parents' knowledge about influenza and the influenza vaccine were not satisfactory. Conclusion: Reliable information from both health care providers during visits and the media about influenza, its severity, and the effectiveness and side effects of its vaccine should be provided.Öğe Factors affecting daily instrumental activities of the elderly(Tubitak Scientific & Technological Research Council Turkey, 2015) Sahin, Ayfer; Tekin, Oguz; Cebeci, Sevsen; Isik, Bunyamin; Ozkara, Adem; Kahveci, Rabia; Canbal, MetinBackground/aim: In order to determine elderly people's capabilities in daily activities, we evaluated the factors that may affect their daily instrumental activities. Materials and methods: We performed an observational, analytical, and cross-sectional study on 101 patients above 60 years of age in 2008 and 2009. We applied the Lawton Instrumental Activity of Daily Living (IADL) scale, the Standardized Mini-Mental State Examination (SMMSE), and the Geriatric Depression Scale (GDS) during one-on-one interviews with the patients. Demographic data and disability levels were also recorded. These data were used to evaluate the possible effects of factors on the IADL scale. Results: Statistical analyses indicated that total scores of instrumental activities are affected negatively by increased age, female sex, and literacy (P < 0.001, P = 0.005, and P = 0.021), whereas scores are affected positively by educational level (P = 0.047). Conclusion: Our findings suggest that increased age, sex, literacy, and education levels influence elderly people's daily instrumental activities. Daily functional activities and factors influencing these activities should be determined in order to increase elderly people's quality of life and independence. It is important to evaluate elderly people's capabilities in daily activities.Öğe Melatonin and caffeic acid phenethyl ester in the regulation of mitochondrial function and apoptosis: The basis for future medical approaches(Pergamon-Elsevier Science Ltd, 2016) Erdemli, Haci Kemal; Akyol, Sumeyya; Armutcu, Ferah; Gulec, Mehmet Akif; Canbal, Metin; Akyol, OmerThe aim of this review article is to summarize and compare the effects of melatonin and caffeic acid phenethyl ester (CAPE) on the relationship between mitochondrial functioning and apoptosis. References in this article were selected with an approach based on a comprehensive literature review by using MEDLINE/PubMed and Google Scholar databaseswhichwere scanned in the last six months without any restrictions. For each database, the review terms used are 'melatonin', 'caffeic acid phenethyl ester, both together and associated with other key words such as apoptosis and mitochondria. Evidential mitochondrial molecular backgrounds for diseases make these twomolecule competitors, since both of themuse the same pathways to copewith fundamentals of the diseases such as nuclear factor kappa-light-chain-enhancer of activated B (NF-kappa B inhibition, induction of mitochondrial apoptosis in cancer cells, free radical scavenging effects, and antioxidant activities. The data reviewed in this paper provide a useful background for the understanding of some molecular details of melatonin and CAPE on several medical situation and diseases. Mutual usage of these two tremendous molecules might have a capacity to open new therapeutic approaches in near future. (C) 2016 Elsevier Inc. All rights reserved.Öğe Relationship between internet addiction and alexithymia among university students(Canadian Soc Clinical Investigation, 2016) Baysan-Arslan, Seher; Cebeci, Sevsen; Kaya, Mehmet; Canbal, MetinPurpose: Epidemiological studies concerning internet addiction found that 50% of internet addicts also have other kinds of psychiatric disorders. This study aims to examine the relationship between alexithymia and internet addiction levels among Turgut Ozal University students in Ankara, Turkey. Method: University students (1,107 students; 452 students from 12 associate degree programs and 655 students from 10 undergraduate programs) participated in the study. The researchers used the personal information form, the Toronto Alexithymia Scale and the Internet Addiction Scale. The approval for the current study was received from the Turgut Ozal University Medical Faculty Clinical Studies Ethics Committee. Results: The number of the alexithymic students was 12.5% whereas the number of the students who were internet addicts was 13.5%. The internet addiction scores were higher among alexithymic individuals than the non-alexithymic (p < 0.001). There was a significant difference in internet addiction average scores between male and female students (p = 0.001). 'Difficulty identifying feeling' scores were higher among females whereas externally oriented thinking' scores were higher among males. Conclusion: The study findings suggest that the internet addiction scores were significantly higher among alexithymic individuals than those who are non-alexithymic. The most obvious reason for this relationship may that alexithymic individuals try to regulate their emotional moods through addictive behavior. There is a need for more comprehensive studies on this subject in the literature.Öğe Repeatability and Reproducibility of Anterior Segment Measurements in Normal Eyes Using Dual Scheimpflug Analyzer(Turkish Ophthalmological Soc, 2015) Altiparmak, Zeynep; Yagci, Ramazan; Guler, Emre; Arslanyilmaz, Zeynel; Canbal, Metin; Hepsen, Ibrahim F.Objectives: To assess the repeatability and reproducibility of anterior segment measurements including aberrometric measurements provided by a dual Scheimpflug analyzer (Galilei) system in normal eyes. Materials and Methods: Three repeated consecutive measurements were taken by two independent examiners. The following were evaluated: total corneal power and posterior corneal power, corneal higher-order wavefront aberrations (6.0 mm pupil), pachymetry at the central, paracentral, and peripheral zones, and anterior chamber depth (ACD). Repeatability was assessed by calculating the within subject standard deviation, precision, repeatability, and intraclass correlation coefficient (ICC). Bland-Altman analysis was used for assessing reproducibility. Results: Thirty eyes of 30 patients were included. The best ICC values were for corneal pachymetry and ACD. For both observers, acceptable ICC was also achieved for the other parameters, the only exceptions being posterior corneal astigmatism and total high order aberration. The 95% LoA (Limits of Agreement) values for all measurements showed small variability between the two examiners. Conclusion: The Galilei system provided reliable measurements of anterior segment parameters. Therefore, the instrument can be confidently used for routine clinical use and research purposes.Öğe Simulation Training for Nursing Students for Lung and Cardiac Auscultation(Canadian Soc Clinical Investigation, 2015) Arslan, Muzeyyen; Altun, Sibel; Basal, Gozde; Dede, Kubra; Demircelik, Muhammet B.; Canbal, Metin; Cebeci, SevsenPurpose: The aim of this study was to evaluate the effects of simulation training in nursing students on the skill of lungs and cardiac auscultation. Methods: The majority (n=70; 85%) of sophomore students attending the Turgut Ozal University, School of Nursing enrolled in the study. Students were divided into two groups: intervention (simulation training) and control (tradition training methods). Stratified sampling method, according to students' grade point averages (GPA), was used to provide homogeneous distribution of experimental and control groups. Survey forms and auscultation skill control lists were designed by the researchers and were used as knowledge collection tools. Results: The average age of the students was 20.5 (min 19, max 34) years and average of these students' grades was 2.5 (min 1.65, max.3.83) points out of 4.0. Knowledge and skill scores for lung and cardiac auscultation were evaluated before and after the simulator training period for both intervention and control groups. Cardiac-lung auscultation knowledge scores improved statistically significantly in both groups (p<0.05). Skill scores increased in both groups immediately after the simulator training period and two months later. No statistical difference was observed in the skill scores (p>0.05) Conclusions: Simulation training contributes to nursing students' education in terms of development of their skills.Öğe The effect of sleep deprivation on heart rate variability in shift and non-shift physicians(Canadian Soc Clinical Investigation, 2015) Cebeci, Sevsen; Canbal, Metin; Yuksel, Ramazan; Cetin, Medine; Caliskan, Yasemin; Dane, SenolPurpose: Higher LF/HF ratio and lower heart rate variability have been reported among shift compared with non-shift workers. We aimed to investigate the possible harmful effects of sleep deprivation on cardiac rhythm, specifically heart rate variability (HRV), in work shift physicians. Patients and Methods: Eighty seven healthy male physicians participated in this study. The present study was done in Ankara, Turkey, from January to September 2014. Work shift (sleep deprivation) group (n=45) remained awake for 26 h. Non-work shift group slept in their homes. ECG (HRV) was applied at 9 am for both shift and non-shift groups. Results: Almost all HRV parameters, except LF/HF, decreased in the work shift group compared with the non-shift group. Conclusions: Sleep deprivation due to work shift may cause sympathovagal imbalances by affecting the biological rhythm.Öğe The Effects of Evoked Left Hemisphere Stimulations in Autistic Children(Canadian Soc Clinical Investigation, 2015) Canbal, Metin; Kaya, Haydar; Kocoglu, Aksel; Telli, Can D.; Kaya, Erkan; Koseoglu, Mehmet; Akgoz, YasinPurpose: Autism is a neurodevelopmental disorder characterized by deficits in social interaction.. It is referred to as cerebral lateralization abnormality. The purpose of this study was to investigate if the different unilateral or lateralized therapeutic applications associated with left cerebral lateralization decreased autistic symptoms. Methods: Autistic symptoms were assessed in six autistic children following stimulation and/or evoking techniques specifically for the left cerebral hemisphere. Results: The use of left cerebral hemisphere stimulation and/or evoking techniques decreased the autistic symptoms in four of the children with autism. Conclusions: These approaches show promise as a technique to restore dominance delay in the left hemisphere in children with autism and can be useful as a complementary treatment to the other modern methods.Öğe Urological recommedations of Hadji Pasha's, a Turkish aged doctor in Anatolia(Mashhad Univ Med Sciences, 2016) Yildirim, Mehmet Erol; Canbal, Metin; Ozyuvali, Ekrem; Karatas, Omer FarukObjective: Urinary tract conditions have been an important part of diseases from antiquity until today. Historically, many plants and herbs have been used for the treatment of urinary disorders. Methods: Celaluddin Hizir bin Ali el-Konevi (Hadji Pasha) is one of the most famous physician who lived in Anatolia between 13th and 14th centuries. He has written one of the most important medical books of that era, Muntehab-iSifa (solution of wellness) in Turkish. General medical information about the diseases in this book, focus on diagnosis and treatment. Results: The herbal solutions for urological disorders such as, urinary incontinence, urinary stones or erection problems are told in this section. Conclusion: Many of the herbal medicines addressed in this book are being widely used in current medicine, but the usage of these herbals in daily urology practice is limited. In this study, we aimed to share the advices for the urological diseases and the related herbal medicines that are named in Hadji Pasha's book, Muntehab-iSifa, with today's physicians.Öğe Vitamin D Deficiency in Children With Newly Diagnosed Idiopathic Epilepsy(Sage Publications Inc, 2015) Sonmez, Fatma Mujgan; Donmez, Ahsen; Namuslu, Mehmet; Canbal, Metin; Orun, EmelSeveral studies have shown a link between vitamin D deficiency and epilepsy. This study includes 60 newly diagnosed idiopathic epilepsy patients and 101 healthy controls (between the ages of 5 and 16). Each group was also divided into two subgroups according to seasonal changes in terms of months of longer versus shorter daylight. We retrospectively evaluated the levels of calcium, phosphorus, alkaline phosphatase, parathyroid hormone, and 25-OH vitamin-D3 in the study participants. Levels below 20 ng/ml were defined as vitamin D deficiency and levels of 20-30 ng/ml as insufficiency. There were no significant differences in age, gender distribution and levels of calcium, phosphorus, alkaline phosphatase and parathyroid hormone between the groups. The level of 25-OH vitamin-D3 in the patient group was significantly lower when compared to the control group (p < 0.05) (14.07 +/- 8.12 and 23.38 +/- 12.80 ng/ml, respectively). This difference also held true when evaluation was made according to seasonal evaluation (12.38 +/- 6.53 and 17.64 +/- 1.14 in shorter daylight and 18.71 +/- 9.87 and 30.82 +/- 1.04 in longer daylight).Öğe What primary care physicians think about insulin initiation in type 2 diabetes: a field-based study(Tubitak Scientific & Technological Research Council Turkey, 2015) Ak, Muharrem; Sucakli, Mustafa Haki; Canbal, Metin; Kosar, YasarBackground/aim: A significant number of patients with type 2 diabetes mellitus require insulin and little is known about the possible physician-related factors that could cause a delay in the initiation of insulin treatment in patients with type 2 diabetes. This study aimed to evaluate those factors. Materials and methods: A total of 87 family physicians working at 36 family health centers in urban Malatya participated in our study on a voluntary basis. A self-administered survey form was structured to gather the views of the primary care physicians. The survey was developed based on a review of the literature. The survey consisted of Likert scale item questions regarding knowledge about the disease of diabetes mellitus and the views of the primary care physicians regarding insulin initiation for type 2 diabetic patients. Results: Almost half of the participants (42.5%, n = 37) felt incompetent in the starting dosage adjustment and 40.2% (n = 35) of the participants felt incompetent in maintaining the appropriate dosage adjustment. In terms of sex, female family physicians were found to be more uncertain about the timing of initiating insulin treatment for diabetic patients. Conclusion: This study shows the necessity of continuous education activities and interventions to promote motivation in family physicians to improve care of diabetic patients in primary care.Öğe Why Fever Phobia Is Still Common?(Kowsar Publ, 2016) Gunduz, Suzan; Usak, Esma; Koksal, Tulin; Canbal, MetinBackground: Fever is a reliable sign of illness, but it also evokes fear and anxiety. It is not the fever itself but the fear of possible complications and accompanying symptoms that is important for pediatricians and parents. Objectives: We aimed to investigate maternal understanding of fever, its potential consequences, and impacts on the treatment of children. Patients and Methods: A questionnaire was use to explore the attitudes, knowledge, and practices of mothers of 861 children brought to four medical centers in different regions of Turkey in 2012, with fever being the chief complaint. All the children were aged 3 months - 15 years. Results: Among the 861 mothers, 92.2% favored antipyretics for fever, either alone or in addition to external cooling measures. Most favored paracetamol or ibuprofen. In this study, the appropriate use of antipyretics was 75.2%, which was higher than that reported in the literature. In common with previous reports, seizures and brain damage were perceived as the most frightening and harmful effects of fever. All the mothers expressed concerns about fever, but they were most common among the highly educated or those with one child. Conclusions: Fever phobia remains common, not only among low socioeconomic status mothers but also among those of high socioeconomic status. Healthcare providers should take fever phobia into account and provide correct information to caregivers about fever at all visits.
