Melatonin and caffeic acid phenethyl ester in the regulation of mitochondrial function and apoptosis: The basis for future medical approaches
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this review article is to summarize and compare the effects of melatonin and caffeic acid phenethyl ester (CAPE) on the relationship between mitochondrial functioning and apoptosis. References in this article were selected with an approach based on a comprehensive literature review by using MEDLINE/PubMed and Google Scholar databaseswhichwere scanned in the last six months without any restrictions. For each database, the review terms used are 'melatonin', 'caffeic acid phenethyl ester, both together and associated with other key words such as apoptosis and mitochondria. Evidential mitochondrial molecular backgrounds for diseases make these twomolecule competitors, since both of themuse the same pathways to copewith fundamentals of the diseases such as nuclear factor kappa-light-chain-enhancer of activated B (NF-kappa B inhibition, induction of mitochondrial apoptosis in cancer cells, free radical scavenging effects, and antioxidant activities. The data reviewed in this paper provide a useful background for the understanding of some molecular details of melatonin and CAPE on several medical situation and diseases. Mutual usage of these two tremendous molecules might have a capacity to open new therapeutic approaches in near future. (C) 2016 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
Melatonin; Caffeic acid phenethyl ester; Mitochondria; Apoptosis; Antioxidant
Kaynak
Life Sciences
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
148
