Melatonin and caffeic acid phenethyl ester in the regulation of mitochondrial function and apoptosis: The basis for future medical approaches

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dc.authoridErdemli, Haci Kemal/0000-0002-3399-4676;
dc.contributor.authorErdemli, Haci Kemal
dc.contributor.authorAkyol, Sumeyya
dc.contributor.authorArmutcu, Ferah
dc.contributor.authorGulec, Mehmet Akif
dc.contributor.authorCanbal, Metin
dc.contributor.authorAkyol, Omer
dc.date.accessioned2025-10-24T18:09:06Z
dc.date.available2025-10-24T18:09:06Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThe aim of this review article is to summarize and compare the effects of melatonin and caffeic acid phenethyl ester (CAPE) on the relationship between mitochondrial functioning and apoptosis. References in this article were selected with an approach based on a comprehensive literature review by using MEDLINE/PubMed and Google Scholar databaseswhichwere scanned in the last six months without any restrictions. For each database, the review terms used are 'melatonin', 'caffeic acid phenethyl ester, both together and associated with other key words such as apoptosis and mitochondria. Evidential mitochondrial molecular backgrounds for diseases make these twomolecule competitors, since both of themuse the same pathways to copewith fundamentals of the diseases such as nuclear factor kappa-light-chain-enhancer of activated B (NF-kappa B inhibition, induction of mitochondrial apoptosis in cancer cells, free radical scavenging effects, and antioxidant activities. The data reviewed in this paper provide a useful background for the understanding of some molecular details of melatonin and CAPE on several medical situation and diseases. Mutual usage of these two tremendous molecules might have a capacity to open new therapeutic approaches in near future. (C) 2016 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.lfs.2016.01.026
dc.identifier.endpage312
dc.identifier.issn0024-3205
dc.identifier.issn1879-0631
dc.identifier.pmid26784848
dc.identifier.scopus2-s2.0-84959018221
dc.identifier.scopusqualityQ1
dc.identifier.startpage305
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2016.01.026
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3466
dc.identifier.volume148
dc.identifier.wosWOS:000371789300037
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofLife Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectMelatonin; Caffeic acid phenethyl ester; Mitochondria; Apoptosis; Antioxidant
dc.titleMelatonin and caffeic acid phenethyl ester in the regulation of mitochondrial function and apoptosis: The basis for future medical approaches
dc.typeReview Article

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