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    The plasma galectin-3 level has high specificity and sensitivity for predicting postoperative atrial fibrillation after coronary artery bypass surgery
    (Verduci Publisher, 2022) Erdem, K.; Kurtoglu, E.; Oc, M.; Oc, B.; Ilgenli, T. F.; Unlu, A.; Onmaz, D. Eryavuz
    OBJECTIVE: Postoperative new -on-set atrial fibrillation (POAF) commonly occurs after coronary artery bypass graft (CABG) surgery. This study aimed to determine the utility of the preop- erative netrin-1 and galectin-3 levels for predict- ing POAF following CABG surgery, as well as that of postoperative serial measurement for assessing these markers' patterns of expression.PATIENTS AND METHODS: This prospec- tive cohort study included 50 patients that un- derwent CABG surgery. The plasma netrin-1 and galectin-3 levels were measured via en- zyme-linked immunosorbent assay (ELISA) be- fore surgery (baseline) and at 6, 12, and 24 h af- ter surgery. The patients were divided into two groups according to the occurrence of POAF; the POAF (+) group and the POAF (-) group. RESULTS: In total, 26 patients developed POAF, whereas 24 remained in sinus rhythm. Base- line galectin-3 levels were higher in the POAF (+) group than in the POAF (-) group (30.7 +/- 10.1 pg mL-1 and 15.7 +/- 3.6 pg mL-1, respectively). The post-CABG surgery galectin-3 level increased in both the POAF (+) and POAF (-) groups at 6 h (46.2 +/- 26.3 pg mL-1 and 24.9 +/- 5.9 pg mL-1, respective- ly), 12 h (45.2 +/- 24.1 pg mL-1 and 26.6 +/- 9.3 pg mL-1, respectively), and 24 h (54.2 +/- 33.5 pg mL-1and 28.6 +/- 7.7 pg mL-1, respectively). The plasma ne- trin-1 level did not differ between groups at base- line or at 6, 12, and 24 h post CABG surgery.CONCLUSIONS: Whereas netrin-1 does not appear to have any utility as a marker for the de- velopment of POAF in CABG surgery patients, the plasma galectin-3 level has high specifici- ty and sensitivity for predicting POAF following CABG surgery and could be considered a mark- er for predicting POAF.