The plasma galectin-3 level has high specificity and sensitivity for predicting postoperative atrial fibrillation after coronary artery bypass surgery
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Verduci Publisher
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: Postoperative new -on-set atrial fibrillation (POAF) commonly occurs after coronary artery bypass graft (CABG) surgery. This study aimed to determine the utility of the preop- erative netrin-1 and galectin-3 levels for predict- ing POAF following CABG surgery, as well as that of postoperative serial measurement for assessing these markers' patterns of expression.PATIENTS AND METHODS: This prospec- tive cohort study included 50 patients that un- derwent CABG surgery. The plasma netrin-1 and galectin-3 levels were measured via en- zyme-linked immunosorbent assay (ELISA) be- fore surgery (baseline) and at 6, 12, and 24 h af- ter surgery. The patients were divided into two groups according to the occurrence of POAF; the POAF (+) group and the POAF (-) group. RESULTS: In total, 26 patients developed POAF, whereas 24 remained in sinus rhythm. Base- line galectin-3 levels were higher in the POAF (+) group than in the POAF (-) group (30.7 +/- 10.1 pg mL-1 and 15.7 +/- 3.6 pg mL-1, respectively). The post-CABG surgery galectin-3 level increased in both the POAF (+) and POAF (-) groups at 6 h (46.2 +/- 26.3 pg mL-1 and 24.9 +/- 5.9 pg mL-1, respective- ly), 12 h (45.2 +/- 24.1 pg mL-1 and 26.6 +/- 9.3 pg mL-1, respectively), and 24 h (54.2 +/- 33.5 pg mL-1and 28.6 +/- 7.7 pg mL-1, respectively). The plasma ne- trin-1 level did not differ between groups at base- line or at 6, 12, and 24 h post CABG surgery.CONCLUSIONS: Whereas netrin-1 does not appear to have any utility as a marker for the de- velopment of POAF in CABG surgery patients, the plasma galectin-3 level has high specifici- ty and sensitivity for predicting POAF following CABG surgery and could be considered a mark- er for predicting POAF.
Açıklama
Anahtar Kelimeler
Postoperative Atrial Fibrillation, Coronary Artery By-Pass Graft, Galectin-3, Netrin-1
Kaynak
European Review for Medical and Pharmacological Sciences
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
26
Sayı
24
