The plasma galectin-3 level has high specificity and sensitivity for predicting postoperative atrial fibrillation after coronary artery bypass surgery

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dc.contributor.authorErdem, K.
dc.contributor.authorKurtoglu, E.
dc.contributor.authorOc, M.
dc.contributor.authorOc, B.
dc.contributor.authorIlgenli, T. F.
dc.contributor.authorUnlu, A.
dc.contributor.authorOnmaz, D. Eryavuz
dc.date.accessioned2026-06-19T06:41:23Z
dc.date.available2026-06-19T06:41:23Z
dc.date.issued2022
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractOBJECTIVE: Postoperative new -on-set atrial fibrillation (POAF) commonly occurs after coronary artery bypass graft (CABG) surgery. This study aimed to determine the utility of the preop- erative netrin-1 and galectin-3 levels for predict- ing POAF following CABG surgery, as well as that of postoperative serial measurement for assessing these markers' patterns of expression.PATIENTS AND METHODS: This prospec- tive cohort study included 50 patients that un- derwent CABG surgery. The plasma netrin-1 and galectin-3 levels were measured via en- zyme-linked immunosorbent assay (ELISA) be- fore surgery (baseline) and at 6, 12, and 24 h af- ter surgery. The patients were divided into two groups according to the occurrence of POAF; the POAF (+) group and the POAF (-) group. RESULTS: In total, 26 patients developed POAF, whereas 24 remained in sinus rhythm. Base- line galectin-3 levels were higher in the POAF (+) group than in the POAF (-) group (30.7 +/- 10.1 pg mL-1 and 15.7 +/- 3.6 pg mL-1, respectively). The post-CABG surgery galectin-3 level increased in both the POAF (+) and POAF (-) groups at 6 h (46.2 +/- 26.3 pg mL-1 and 24.9 +/- 5.9 pg mL-1, respective- ly), 12 h (45.2 +/- 24.1 pg mL-1 and 26.6 +/- 9.3 pg mL-1, respectively), and 24 h (54.2 +/- 33.5 pg mL-1and 28.6 +/- 7.7 pg mL-1, respectively). The plasma ne- trin-1 level did not differ between groups at base- line or at 6, 12, and 24 h post CABG surgery.CONCLUSIONS: Whereas netrin-1 does not appear to have any utility as a marker for the de- velopment of POAF in CABG surgery patients, the plasma galectin-3 level has high specifici- ty and sensitivity for predicting POAF following CABG surgery and could be considered a mark- er for predicting POAF.
dc.identifier.endpage9078
dc.identifier.issn1128-3602
dc.identifier.issue24
dc.identifier.orcid0000-0002-2253-5191
dc.identifier.orcid0000-0003-3113-0548
dc.identifier.pmid36591819
dc.identifier.scopus2-s2.0-85145345626
dc.identifier.scopusqualityN/A
dc.identifier.startpage9072
dc.identifier.urihttps://hdl.handle.net/20.500.12899/6221
dc.identifier.volume26
dc.identifier.wosWOS:000914641100003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260612
dc.subjectPostoperative Atrial Fibrillation
dc.subjectCoronary Artery By-Pass Graft
dc.subjectGalectin-3
dc.subjectNetrin-1
dc.titleThe plasma galectin-3 level has high specificity and sensitivity for predicting postoperative atrial fibrillation after coronary artery bypass surgery
dc.typeArticle

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