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    Synthesis and evaluation of anticancer properties of novel benzimidazole ligand and their cobalt(II) and zinc(II) complexes against cancer cell lines A-2780 and DU-145
    (Elsevier, 2019) Yılmaz, Ülkü; Tekin, Suat; Buğday, Nesrin; Yavuz, Kemal; Küçükbay, Hasan; Sandal, Süleyman
    Eighteen new cobalt(II) or zinc(II) complexes of benzimidazole bearing 1-benzyl and 2-phenyl moieties were synthesized from the reaction of appropriate benzimidazole ligands and CoCl2 or ZnCl2. Their structural characterizations were done by IR, NMR (1H, 13C) and UV–VIS spectrometers. Cytotoxic activities of eighteen new complexes and three benzimidazole ligands were determined using A-2780 (human ovarian) and DU-145 (human prostate) cell lines. Antitumor properties of all compounds were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell viability assay for the tested benzimidazole derivatives was performed and the LogIC50 values of the compounds were calculated after a 24-hour treatment. All tested benzimidazole derivatives showed higher or comparable antitumor activity against A-2780 cell lines compared to the standard drug docetaxel with a LogIC50 value of ?0.81?µM (p?
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    The Macroeconomic Effects of Earthquakes in Turkey and Sustainable Economic Resilience: A Time Series Analysis, 1990-2023
    (Mdpi, 2025) Ulger Danaci, Ozlem; Gokkaya, Emrah; Yavuz, Kemal; Demirbilek, Omer
    This study examines the macroeconomic impacts of major earthquakes in T & uuml;rkiye using annual data from 1990 to 2023. Despite growing global interest in disaster economics, evidence on how large seismic events shape national economic performance over extended periods remains limited, particularly in emerging economies. Using data from the World Bank, the Central Bank of the Republic of T & uuml;rkiye, and the Disaster and Emergency Management Authority, the analysis incorporates real gross domestic product, gross fixed capital formation, consumer prices, and export capacity. A dummy variable identifies years with high-fatality earthquakes. After confirming stationarity, Johansen cointegration and a Vector Error Correction Model were applied. Results indicate that earthquakes exert a statistically significant negative influence on long-term economic growth. Based on the log-level specification, the long-run equilibrium level of real gross domestic product in earthquake years is approximately 45 percent lower than in non-earthquake years. Investment, price stability, and trade capacity support long-term growth. Model diagnostics confirm stability, normality, and no autocorrelation. These findings highlight the structural economic vulnerabilities created by major earthquakes and underscore that disaster risk reduction and resilient infrastructure policies must be integral components of sustainable growth strategies. The study contributes updated national time-series evidence from a structurally fragile context.