Temel Tıp Bilimleri Bölümü Koleksiyonu

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PEDODONTİ PRATİĞİNDE STRES ÖLÇEĞİ"NİN GELİŞTİRİLMESİ: GEÇERLİLİK VE GÜVENİLİRLİK ÇALIŞMASI
(25.03.2021) İnceoğlu,Feyza
Diş hekimliği öğrencilerinin diğer bölümlere göre daha depresif, anksiyetik ve stresli olduğu yapılan araştırmalarda gösterilmiştir. Bu çalışmanın amacı Pedodonti Pratiğinde Stres (PPS) ölçeğini geliştirmektir. Bu çalışmaya, 2018-2019 ve 2019-2020 eğitim-öğretim yıllarında İnönü Üniversitesi Diş Hekimliği Fakültesi pedodonti kliniğinde staj yapan 4. ve 5. sınıf öğrencileri dâhil edilmiştir. Pedodonti kliniğinde stres kaynağı olabilecek faktörler, uzman görüşleri de alınarak kategorize edilmiş ve 4 alt boyutlu 29 maddeden oluşan PPS ölçeği geliştirilmiştir. Formun geçerliliğini belirlemek için Açıklayıcı ve Doğrulayıcı Faktör Analizleri (DFA) ve kapsam geçerlilik indeksi yöntemleri kullanılmıştır. Ölçek güvenilirliği; Cronbach ? iç tutarlık kat sayısı, madde toplam korelasyonu, test-tekrar test analizi ile test edilmiştir. PPS ölçeği için DFA uyum indeksi değerleri istenilen aralıkta, Cronbach ? güvenilirlik katsayısı 0,915 bulunmuştur. PPS ölçeğinin pedodonti kliniklerinde oluşabilecek stresi değerlendirmek için yararlanabilecek geçerli ve güvenilir bir araç olduğu belirlenmiştir. PPS ölçeğinin kullanımı ile pedodonti kliniklerinde stres oluşturarak; hekimin verimliliği, hastanın uyumu ve dolayısıyla tedavinin etkinliğini dahi etkileyebilecek stres faktörlerinin belirlenmesi mümkün olabilecektir.
Evaluation of the relationship between nasal septal deviation and development of facial asymmetry with anthropometric measurements depending on age: The effect of nasal septum deviation on craniofacial asymmetry and somatotype
(Elsevier, 2022) Arpacı, Muhammed Furkan; Özbağ, Davut; Aydın, Şükrü; Şenol, Deniz; Baykara, Rabia Aydoğan; Çiçek, İpek Balıkçı
Aim: It was aimed to determine the change of facial asymmetry resulting from nasal septal deviation (SD) depending on age, gender, degree of deviation and the affected area besides the effect of SD on somatotype and craniofacial morphology. Materials and methods: 171 volunteers (90 males, 81 females), 27 individuals aged 9–13, 44 individuals aged 14–18, 44 individuals aged 19–23 and 56 individuals in control group participated in the study conducted in otorhinolaryngology polyclinic.11 photometric, 16 anthropometric measurements were taken from the participants. Results: SD affects facial asymmetry formation, although not statistically significant compared to healthy individuals asymmetry rates (p?0.05). It was determined that the degree of SD affected asymmetry only between the ages of 14–18 (in adolescence) and the development of asymmetry in all SD patients was not statistically dependent on age and gender (p?0.05). Photometric measurements demonstrated asymmetries in horizontally-extending parameters of 1/3 middle part of face. There was no statistically significant difference in the cranial anthropometric measurements of the upper and lower 1/3 of the face compared to the control group (p?0.05). The order of the most asymmetrical parameters is Alare-Zygion, Alare-Subnasale, Cheilion-Gonion, Exocanthion-Cheilion, Midsagittal plane-Zygion, Zygion-Cheilion, Zygion-Gonion, Subalare-Cheilion, Glabella-Exocanthion. In all participants were determined that endomorph somatotype was dominant in female and mesomorph somatotype was dominant in male besides SD did not affect somatotype and somatotype did not alter with age. Conclusion: The development of facial asymmetry due to SD is not affected by age and gender furthermore SD does not affect craniofacial asymmetry and somatotype.
Evaluation of the efferent auditory system in COVID-19 adult patients
(Taylor & Francis, 2022) Emekci, Tuğba; Dündar, Mehmet Akif; Kirazlı, Gülce; Men Kılınç, Fatma; Cengiz, Deniz Uğur; Karababa, Ercan; İnceoğlu, Feyza; Arbağ, Hamdi
Background: The short- and long-term effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the medial olivocochlear reflex and outer hair cells in the cochlea remain largely unclear. Aims: The aim of this study was to investigate the efferent auditory system effects in adult patients with COVID-19. Materials and methods: The study included 18–50 years old 44 volunteers: 26 individuals (52 ears) with COVID-19 in the study group and 18 healthy individuals (36 ears) in the control group. Otolaryngological examination, immitancemetric evaluation, distortion product otoacoustic emission (DPOAE), contralateral acoustic stimulation with DPOAE, audiometric evaluation, and high frequency audiometric evaluation were performed in all individuals participating in the study. Results: In our study, patients with COVID-19 had significantly lower DPOAE results with or without broadband noise at only 6 kHz frequency and contralateral suppression results at all frequencies compared to healthy individuals. A statistically significant difference was found between the study and control groups according to whether the participants had a response in the high frequency audiometry at 12 and 16 kHz frequencies. Conclusions: COVID-19 affects many systems in the body. As a result of the findings obtained in the present study, it is shown that the auditory efferent system may also be affected.
COVID-19 Hastalarında Semptomatik Reenfeksiyonlar: Aşılama Öncesi Dönemde Retrospektif Bir Çalışma
(2021-08-08) Gündüz, Ayten; Türkoğlu, Gamze; Yakupoğulları, Yusuf
Bu çalışmada COVID-19 (Coronavirus Disease 2019) hastalığına neden olan yeni koronavirus (SARSCoV-2; Severe acute respiratory syndrome coronavirus-2) tanısı için yapılan gerçek zamanlı polimeraz zincir reaksiyonu (RT-PCR) testi pozitif olan hastalarda reenfeksiyon oranlarını ve bu enfeksiyonların özelliklerini irdelemek ve literatür bilgileriyle karşılaştırmak amaçlanmıştır. Çalışmada 01.03.2020 ile 31.12.2020 tarihleri arasında COVID-19 şüphesi ile hastanemize başvuran ve SARS-CoV-2 RT-PCR test sonucu pozitif çıkan 27.354 kişinin laboratuvar testi sonuçları ve hastalık bilgileri geriye dönük olarak tarandı. Hastaların ilk SARS-CoV-2 RT-PCR test pozitiflik tarihleri kaydedildi. Daha sonra ilk pozitifliği izleyen süreçte art arda en az birer hafta arayla yapılan iki kez test sonucu negatif çıkan olgular tespit edildi ve bu olgulardan tekrar test sonucu pozitif olanlar saptandı (%0.19; 36/18.726). İlk pozitiflik ile ikinci pozitiflik arasındaki sürenin en az 3 ay (90 gün) olduğu vakalar reenfeksiyon olguları olarak (18/18.726, %0.096) çalışmaya dahil edildi. Olguların 10’u (%55.6) kadın ve 8’i (%44.4) erkek hasta iken, yaş ortalaması 40.44 ±17.42 (18-74) idi. Birinci SARS-CoV-2 pozitifliği ile ikinci pozitiflik arasındaki ortalama süre 123.33 ±31.62 (90-190) gün olarak saptandı. Hastaların akciğer bilgisayarlı tomografi pozitiflik ve negatiflik oranları sırasıyla %16.7 (3/18) ve %83.3 (15/18) olarak tespit edildi. Kronik hastalığı olanların oranı %50 (9/18) iken, olmayanların oranı %50 (9/18) idi. Hastaların %11.1’i (2/18) sağlık çalışanı iken %88.9’u (16/18) sağlık çalışanı değildi. İlk ve ikinci enfeksiyonlar için laboratuvar bulguları karşılaştırıldığında laktat dehidrogenaz, C-reaktif protein, nötrofil, lenfosit, ferritin ve prokalsitonin değerleri için istatistiksel olarak anlamlı bir fark saptanmazken (p>0.05), lökosit sayıları (azalma) ve D-dimer değerlerinde (artış) anlamlı farklılıklar saptandı (sırasıyla p=0.043 ve p=0.035). Reenfeksiyon olgularının üçü %16.7 (3/18) ölümle sonuçlandı. Çalışmamız COVID-19 hastalığında iyileşme sonrası ilk 3-6 aylık dönemde reenfeksiyonların oldukça düşük oranda olduğunu, ancak kalıcı bir bağışıklık gelişmediğini göstermektedir. Prospektif ve çok merkezli çalışmaların yapılması reenfeksiyon oranlarının ve bu hastalarda klinik seyrin değerlendirilmesi için önemli olacaktır. Sunulan bu verilerin hastalığa yönelik tedavi süreçlerine ve koruyucu önlemlerin alınması için yapılacak planlamalara katkı sağlayacağı kanaatindeyiz.
Various Benefits Of Apricot To Our Health
(şubat 2021) Kıran,Tuğba Raika; Karabulut, Ercan; Otlu, Önder
VARIOUS BENEFITS OF APRICOT TO OUR HEALTH
Turkish validity and reliability study for the person-centered maternity care scale
(13 haziran 2021) İnceoğlu,Feyza; Özşahin, Zeliha; Altiparmak, Sümeyye; Aksoy Derya, Yesim; Kayhan Tetik, Burcu
Aim: The objective was to adapt the person-centered maternity care scale (PCMCS) developed by Afulani et al. in 2017 to Turkish and to perform the validity and reliability study of this scale. Methods: The population of this methodological study consisted of 280 mothers who were referred to the postpartum service of a public hospital in eastern Turkey. Linguistic validity, context validity, and pilot practice studies regarding the PCMCS that could be used in the first nine postpartum weeks were per formed. Explanatory factor analysis and confirmatory factor analysis were performed to assess the construct validity of the form. Reliability of PCMCS was tested through the Cronbach’s ? internal consistency coeffi cient, total item correlation, and test–retest analysis. Results: The Turkish version of the PCMCS a 21-item scale with three sub-dimensions was obtained. These three sub-dimensions found as a result of explanatory factor analysis and confirmatory factor analysis supported the scale structure. Cronbach’s ? reliability coefficient scale was adequate for total and sub dimensions. Conclusion: Turkish version of PCMCS was found to be a valid and reliable instrument to be used for assessing the person-centered maternity care for women in the postpartum period
Forecasting Model to Predict the Spreading of the COVID-19 Outbreak in Turkey
(2021) Kıran,Tuğba Raika; Bereketoglu, Ceyhun; Ozcan, Nermin; Yola, Mehmet Lutfi
This study aimed to forecast the future of the COVID-19 outbreak parameters such as spreading, case fatality, and case recovery values based on the publicly available epidemiological data for Turkey. We first performed different forecasting methods including Facebook’s Prophet, ARIMA and Decision Tree. Based on the metrics of MAPE and MAE, Facebook’s Prophet has the most effective forecasting model. Then, using Facebook’s Prophet, we generated a forecast model for the evolution of outbreak in Turkey fifteen-days-ahead. Based on the reported confirmed cases, the simulations suggest that the total number of infected people could reach 4328083 (with lower and upper bounds of 3854261 and 4888611, respectively) by April 23, 2021. Simulation forecast shows that death toll could reach 35656 with lower and upper bounds of 34806 and 36246, respectively. Besides, our findings suggest that although more than 86.38% growth in recovered cases might be possible, the future active cases will also significantly increase compared to the current active cases. This time series analysis indicates an increase trend of the COVID-19 outbreak in Turkey in the near future. Altogether, the present study highlights the importance of an efficient data-driven forecast model analysis for the simulation of the pandemic transmission and hence for further implementation of essential interventions for COVID-19 outbreak.
Complications related to COVID-19 infection in neurological diseases
(CMJ, 15 aralık 2021) Kıran,Tuğba Raika; Bay Karabulut, Aysun; Bolayır, Aslı
Neurological signs and symptoms constitute at least 35% of the findings reported from the beginning of the coronavirus-19 (COVID-19) epidemic until now. Neurological symptoms based on myopathy,headache,taste and smell disorders,dizziness, impaired consciousness, encephalitis, and peripheral nervous system disorders such as Guillain-Barré and Miller Fisher syndromes, have been described. We aimed to provide information on how COVID-19 infection affects neurological system and possible damage mechanisms.This review has been prepared by scanning severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19, coronavirus, neurological symptoms, results, pandemic keyword combinations in the database. In the literature review, a total of 57 articles, including case series, case report, letter, article and review, were reached on the neurological disorders associated with COVID-19 in the last two years.If the patient is older, the COVID-19 infection may be more severe. Hypertension, obesity, diabetes, and cardiovascular diseases also make more challenging the clinical cases. In addition, patients with a history of neurological disorders and acute respiratory symptoms appear to be at higher risk of encephalopathy
Effect of Altered Iron Metabolism on Hyperinflammation and Coagulopathy in Patients with Critical COVID-19: A Retrospective Study
(JAMP, 15.01.2022) Kıran,Tuğba Raika; Otlu, Önder; Erdem, Mehmet; Korkmaz, Kübranur; Ota Günay, Özge; İn, Erdal; Bay Karabulut, Aysun
Abstract: A novel coronavirus disease 2019 (COVID-19) outbreak has started in Wuhan, China, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The relationship between altered iron homeostasis and hyperinflammation may be hallmarks of COVID-19 disease. We aimed to compare some iron (ferritin and iron), inflammation (C-reactive protein [CRP], hemoglobin, lactate dehydrogenase [LDH], neutrophil) and coagulation (prothrombin time [PT], activated partial thromboplastin time [APTT], D-dimer, platelet) marker results of critical COVID-19 patients with healthy controls results. In this single center retrospective study, 50 critical patients diagnosed with COVID-19 were included, demographic, clinical characteristics, severity of disease and laboratory test results were elicited from electronic medical records and compared to 50 healthy people. A statistically significant increase in CRP, LDH, neutrophil, PT, APTT, D-dimer ferritin levels was observed in critical COVID-19 patients compared with healthy people while a statistically significant decrease was observed in hemoglobin and iron levels. In addition, no statistically significant change in platelet levels was observed. Ferroptosis may be a significant cause of multiple organ failure in critical COVID-19 patients. Ferroptosis inhibitors might have potential to combat ferroptosis in COVID-19. Therefore, larger studies are needed to ferroptosis in COVID-19 in vivo and in vitro.
Adaptation of Fear of Missing Out Scale (FoMOs) to Dentistry
(10 haziran 2021) İnceoğlu,Feyza; Aydoğdu, Hatice; Demir, Pınar
Background: The objective was to adapt the Fear of Missing Out Scale (FoMOs) Scale developed by Przybylski et al in 2013 to Turkish and to perform the validity and reliability study of this scale. Methods: This study was designed as a methodological study, and the adapted questionnaire was completed by 1142 dental students educating in 59 universities in Turkey. The answers given were evaluated according to the original scale and its validity and reliability were tested. Explanatory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) were performed to assess the construct validity of the form. The reliability of FoMOs was tested through the Cronbach’s ? internal consistency coefficient, total item correlation, and test-retest analysis. Results: Different from the original FOMO obtained in the study, it consisted of 2 sub-dimensions and a total of 10 items. Item 10 was excluded owing to the low factor loads. Accordingly, the "10- item scale" with two sub-dimensions was obtained. The 2 sub dimension scale structure found as a result of EFA was supported by the result obtained in DFA. The Cronbach alpha reliability coefficient was found to be 0.840 for the FoMOs total score, 0.919 for the "trait" sub-dimension, and 0.718 for the "state" sub-dimension. Conclusion: This scale was made to define and analyze the concept of FoMO in dentistry postgraduate career planning. The current scale is a valuable and reliable tool to guide the idea behind career planning and provides a great contribution to the literature
The Radiological Evaluation of the Mastoid Process and Its Implications for Surgical Approaches
(07.02.2021) İnceoğlu,Feyza
Background and objective In various surgical procedures, in approaching the posterior fossa and the posterolateral cranial base, surface markings are used to locate the groove for transverse and sigmoid sinuses, and their junction. Determining these surface landmarks, especially the mastoid bone and its surrounding anatomical formations, is extremely valuable. The purpose of this study was to examine the anatomical features and the relationship between the mastoid process and surrounding structures on cone-beam CT (CBCT) images. Methods Before starting this retrospective study, approval was obtained from the Ethics Committee of Gaziantep University (approval date: 04/12/2019; number: 470). Individuals who consulted the Department of Oral and Maxillofacial Radiology of Gaziantep University's Faculty of Dentistry between 2015-2018 for any reason and whose CBCT images were taken were included in this study. Frankfort horizontal plane was used for the standardization of the images. Measurements were made on three different sections: coronal, transverse, and sagittal. Results The cohort consisted of 149 females and 98 males; the mean age of the participants was 45.72 ± 17.12 years. It was determined that homogeneity was achieved in terms of data distribution between genders according to age (p=0.777). Additionally, it was determined that there was a statistically significant difference between the genders in all parameters except anterior inclination angle (AIA), and higher values were found in males. Conclusion We believe that the results obtained from this study may contribute toward decreasing the complication rate and increasing success in surgical procedures, especially with respect to approaching the posterior fossa and the posterolateral cranial base.
The Moderating Role Of Actual And Psychological Birth Order In The Relationship Between Family Functionality, Roles, And Codependence In Women
(2021) İnceoğlu,Feyza; ULUSOY, Yağmur
The purpose of this study is to examine the relationship between family roles, family functioning, and codependency, and whether the effect of actual birth order and psychological birth order on this relationship differ. The correlational survey model was used in this study. The sample of the study consists of 501 female students between the ages of 17 and 40 studying at İnönü University, Faculty of Education. Composite Codependency Scale, McMaster Family Evaluating Scale and White-Campbell Psychological Birth Order Inventory were used as a data collection tools. The data obtained were analyzed with SPSS 25.0 and AMOS 24 statistical package programs. The findings obtained from the study predict both general functioning and codependency of roles in positively and significantly. However, the mediating role of family functioning in the relationship between roles and codependency was not found significant. The moderator roles of psychological birth order and actual birth order being the same and different are significant in the relationship between roles, general functionality, and interdependence. It was observed that those with different psychological birth order and actual birth order had a higher moderator effect of roles on both general functioning and codependency than those with the same. The findings obtained from the study were discussed in the light of the literature, and various suggestions were presented to researchers and parents
Koranavirüs Hastalığının Önlenmesi ve Tedavisi İçin Şifalı Bitkiler
(2021) Otlu, Önder; Bereketoğlu, Ceyhun; Kıran, Tuğba Raika; Bay Karabulut, Aysun
2019-nCoV (yeni Korona Virüsü) salgını Uluslararası Acil Halk Sağlığı Kuruluşu olan Dünya Sağlık Örgütü (WHO) tarafından 30 Ocak 2020'de ilan edildi ve DSÖ 12 Şubat'ta, 2019-nCoV patojenini SARS-CoV-2 ve Corona virüs Hastalığı 2019 (COVID-2019) olarak adlandırdı. COVID-19 11 Mart 2020’de resmi olarak WHO tarafından Pandemi olarak kabul edildi. Bitkiler tüm dünyada, viral hastalıklar da dahil olmak üzere birçok kronik enfeksiyonu tedavi etmek için yüzyıllardır geleneksel ilaç olarak kullanılmaktadır. Son yıllarda, bilim adamları fonksiyonel ve nutrasötik gıdalar üzerinde yaptıkları araştırmalarla fonksiyonel bileşiklerin insan sağlığını koruma ve hastalıkları iyileştirme potansiyelini doğrulamaya çalışmaktadırlar. Geleneksel tıbbi bitkiler, sağlıklı yaşamın sürdürülmesi, günlük hayatta alınan toksinler, hastalıklarla mücadele ve önleme, uzun ömür gibi birçok araştırma ile desteklenmiş uzun bir geçmişe sahiptir. Etnomedikal bitkiler ve doğal fitokimyasalların antiviral, antiinflamatuar ve antioksidan özellikleri üzerine yapılan araştırmalar, Covid-19 tedavisinin yanısıra çeşitli rahatsızlıklara karşı büyük bir potansiyel ilaç kaynağı olarak kabul edilebilir. Bu çalışmadan yola çıkarak bitki özütlerinin Covid-19 gibi ölümcül sonuçlara yol açabilen viral enfeksiyonlarda beyaz kan hücrelerinin ve lenfositlerin sayısındaki yükselişle bağışıklığa arttırma, proinflamatuar sitokinlerin üretimini ve salımını düzenleme, C-reaktif protein ve eritrosit sedimantasyon oranındaki düşüşle anti-inflamatuar bir etki gösterme, virüsün gelişimine müdahale etme gibi olumlu etki ve potansiyel antiviral ajan aktivitesi sergilediği görülmektedir. Bu çalışmada COVID-19 enfeksiyonu ile ilişkili fitokimyasallar ve etkileri derlenmiştir
Comparison of the effects of conventional physiotherapy and proprioception exercises on pain and ankle proprioception in patients with lumbar radiculopathy
(2022) Deniz, Şenol; Erdem, Cumali; Canbolat, Mustafa; Toy, Seyma; Karatas, Turgay; Baykara, Rabia Aydogan; Ozbag, Davut; Akyurek, Gokcen
BACKGROUND: Lumbar radiculopathy is characterized by a significant amount of backache causing loss of workforce and is a significant health problem frequently seen in the general population. OBJECTIVE:The purpose of this study was to compare the effects of conventional physiotherapy (CT) and proprioception exercises (PE) on ankle proprioception and lumbar pain between patients with lumbar radiculopathy and a healthy control group. METHODS:In this randomized clinical trial, 89 patients referred to the Physical Medicine and Rehabilitation outpatient clinic were selected through convenience sampling. They were randomly assigned to three groups: CT (n= 27), PE (n= 31), CT&PE (n= 31). Thirty healthy volunteers were included in the study as the control group. Proprioception measurements were made with an isokinetic dynamometer at 10? dorsiflexion (DF), 11?, and 25? plantarflexion (PF) angles. Lumbar pain was assessed by using the Numerical Pain Rating Scale (NPRS). The data were analyzed by IBM SPSS Statistics version 22.0 via the Kruskal-Wallis and Mann-Whitney U tests. RESULTS: There was a statistically significant difference between the groups in terms of ankle proprioception and NPRS measurements in post-treatment evaluations (p< 0.05). Statistically significant differences were found between CT and PE groups and CT&PE and control groups. There was no statistically significant difference in comparing CT and PE groups and CT&PE and control groups within themselves (p> 0.05). CONCLUSION: The combined use of CT and PE is an effective method that can be used in the clinic to reduce angular differences in ankle proprioception which is one of the primary factors of balance and coordination and lumbar pain.
Protective Effects of Grape Molasses and Resveratrol Against DMBA Induced Oxidative Stress in Rat Ovarian Tissues
(2019) Kıran, Tuğba Raika; Otlu, Önder; Karabulut, Ercan; Bay Karabulut, Aysun
Objective: The polyphenolic compound, resveratrol (3, 4’, 5-trihydroxystilbene), trans-resveratrol is a natural phytoalexin that exists in many different foods such as grape peel and seed, peanut, mulberry and blueberry. Molasses is a natural food obtained by boiling and concentrating fruit juices known to be rich in minerals such as iron, phosphorus, potassium, sodium, calcium and magnesium, and phosphoric acid, formic acid, organic acids and some vitamins. Polyphenolic compounds are natural antioxidants and are known to have protective effects against tissue damage caused by reactive oxygen species (ROS). In this study, we aimed to investigate the protective effects of grape molasses and resveratrol on ovarian damage induced by 7, 12-dimethylbenz [a] anthracene (DMBA). Methods: A total of 42 old female Wistar Albino rats, aged 18 weeks were divided into six groups. 10 mg/kg DMBA was injected in the rats in DMBA group subcutaneously on day 0 and day 7 while grape molasses feed with 20% grape molasses was given along with DMBA application to the rats in DMBA + grape molasses group. Resveratrol was administered by subcutaneous injection at 10 mg/kg/day to the DMBA + Resveratrol group, while only feed with 20% grape molasses was given to the grape molasses group. Resveratrol was administered by subcutaneous injection at 10 mg/kg/day to the resveratrol group. Results: GSH activity between the control group and molasses group, DMBA and DMBA + molasses groups and the control group and the DMBA + grape molasses groups was found statistically significant. Regarding the NO activity, the difference between the DMBA and resveratrol groups, DMBA and DMBA + resveratrol groups and the grape molasses and resveratrol groups was found statistically significant. MDA activity between DMBA + resveratrol and DMBA + grape molasses groups, and DMBA + grape molasses and grape molasses groups was found statistically significant. Conclusion: Molasses as one of the most important nutrient sources of Eastern and Central Anatolia was observed to decrease ovarian tissue oxidative damage induced with DMBA compared to resveratrol.
Effect of Altered Iron Metabolism on Hyperinflammation and Coagulopathy in Patients with Critical COVID-19: A Retrospective Study
(2022) Otlu, Önder; Erdem, Mehmet; Korkmaz, Kübranur; Günay, Özge Ota; İn, Erdal; Kıran, Tuğba Raika; Bay Karabulut, Aysun
Abstract: A novel coronavirus disease 2019 (COVID-19) outbreak has started in Wuhan, China, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The relationship between altered iron homeostasis and hyperinflammation may be hallmarks of COVID-19 disease. We aimed to compare some iron (ferritin and iron), inflammation (C-reactive protein [CRP], hemoglobin, lactate dehydrogenase [LDH], neutrophil) and coagulation (prothrombin time [PT], activated partial thromboplastin time [APTT], D-dimer, platelet) marker results of critical COVID-19 patients with healthy controls results. In this single center retrospective study, 50 critical patients diagnosed with COVID-19 were included, demographic, clinical characteristics, severity of disease and laboratory test results were elicited from electronic medical records and compared to 50 healthy people. A statistically significant increase in CRP, LDH, neutrophil, PT, APTT, D-dimer ferritin levels was observed in critical COVID-19 patients compared with healthy people while a statistically significant decrease was observed in hemoglobin and iron levels. In addition, no statistically significant change in platelet levels was observed. Ferroptosis may be a significant cause of multiple organ failure in critical COVID-19 patients. Ferroptosis inhibitors might have potential to combat ferroptosis in COVID-19. Therefore, larger studies are needed to ferroptosis in COVID-19 in vivo and in vitro.
Investigation of the Effects of Sun-Dried Apricot with Different Sulfur Levels on Oxidative Stress Markers
(2019) Kıran, Tuğba Raika; Otlu, Önder; Karabulut, Ercan; Özcan, Nermin
Objective: Apricots are mostly consumed in dried form worldwide. Studies are reporting some allergic effects of dried apricot because of its content of sulfur, which is used in the drying process. Therefore sulphur content has been limited by many countries. This study was conducted to determine the effects of sun-dried apricots with different sulfur contents on nitric oxide (NO), malondialdehyde (MDA) and glutathione (GSH) that are among the markers of oxidative stress. Methods: A total of 84 Wistar albino rats were divided into groups as control, sun-dried apricot, 1000, 2000, 3000 and 4000 ppm sulfured groups. At the end of the 12th week, rats were sacrificed under general anesthesia. NO, MDA and GSH levels were studied at the end of the experiment from the ovarian and testicular tissues of the rats. Results: No statistically significant differences were found among the groups in terms of NO, MDA and GSH in the ovarian and testicular tissues removed from the rats Conclusion: We claim that sulfur amount of dried apricots is not affect on reproductive system. This study is guiding further studies that will be conducted against the restrictions in sulfur used in the drying process of dried apricots, which is economically very important for dried fruits sector.
Long-term effects of orchiopexy and orchiectomy on the testes of rats with testicular torsion
(elsevier, 2022) Taşçı, Aytaç; Uğuralp, Sema; Akatlı , Ayşe Nur; Arslan ,Ahmet Kadir; Bay Karabulut, Aysun
Introduction: Ischemia/reperfusion injury occurs after testicular torsion, levels of free oxygen radicals and inflammatory cytokines are increased in both the torsional and contralateral testis, leading to testicular injury. Objective: The present study investigated whether orchiopexy or orchiectomy after testicular torsion was superior in terms of fertility potential in the long term. Study design: Following 720°, 4h left testicular torsion, orchiectomy or orchiopexy was performed on 84 rats, which were then sacrificed and evaluated for testicular function at day 1, at 3 months and 6 months (n=14 per group). An additional 14 rats were in the control group. Results: Follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels were significantly lower in the orchiopexy group than the orchiectomy and control groups after 3 months. However, there were no significant differences in hormone parameters among the three groups after 6 months. The hormone levels, Johnsen score, seminiferous tubule diameter, and inducible nitric oxide synthase (iNOS) expression at 3 and 6 months were not significantly different between the orchiectomy group and controls. Histopathological analyses at 3 and 6 months indicated significant decreases in Johnsen score and seminiferous tubule diameter in the ipsilateral testis in the orchiopexy group. At 3 months, the level of iNOS expression in the contralateral testis was significantly lower in the orchiopexy group than in other groups. At 6 months, however, it was not significantly different between the orchiopexy and control groups. There were no significant differences in iNOS expression at 3 or 6 months in the orchiectomy group compared to controls. Discussion: The ipsilateral testis in the orchiopexy group began to atrophy at 3 months, and the degree of atrophy became more evident at 6 months. The level of iNOS expression was low in the bilateral testis at 3 months in the orchiopexy group, and sperm in the contralateral testis were not yet functionally healthy. The level of iNOS expression in the ipsilateral testis decreased further at 6 months in the orchiopexy group, while that in the contralateral testis returned to the normal level. Conclusion: Testicular functions were restored faster after orchiectomy compared to orchiopexy following testicular torsion. However, follow-up of the rats for 6 months demonstrated that orchiopexy or orchiectomy procedures conducted on the testicular torsion had no effect on future fertility potential after 4 hours of torsion.
Clinical Practice of Women’s Health Nursing Lesson in Turkey of Analysis: An Example of University
(Institute of Medico-Legal Publications, 2020) Kaplan, Sena; Şahin, Sevil; Arıöz Düzygün, Ayten; Abay, Halime; Bükecik, Esra
Objectives: The aim of this study was to conduct a “Strengths-Weaknesses-Opportunities-Threats”(SWOT) analysis in order to assess strengths and weaknesses, threats and opportunities clinical practice of women’s health nursing lesson (CPWHN) is facing. Method: Embedded single-case research design was used in this study conducted with methodology of qualitative research. Academicians and mentor nurse trainers who were teaching women’s health nursing lesson were included in this study (n=13). Case analysis method was used to assess the data. Finding: Strengths of CPWHN included the university being located in the capital of Turkey and certain application hospitals offering case variety. Its weaknesses included failure to provide individualized education due to high quotas for nursing students, lack of interest in CPWHN among male students due to gender stereotypes. Opportunities of CPWHN included national and international exchange programs for both students and academicians in addition to developments in innovative health practices; whereas the threats it was facing included opening nursing programs at universities with insufficient academicians and high quotas for nursing students due to high demand in nursing work force. Conclusions: Improving weaknesses and turning threats into opportunities for CPWHN would be beneficial in improving quality of nursing care after graduation.
Protective Effects of Grape Molasses and Resveratrol Against DMBA Induced Oxidative Stress in Rat Ovarian Tissues
(Ordu Üniversitesi, 2019) Kıran, Tuğba Raika; Karabulut, Ercan
Objective: The polyphenolic compound, resveratrol (3, 4’, 5-trihydroxystilbene), trans-resveratrol is a natural phytoalexin that exists in many different foods such as grape peel and seed, peanut, mulberry and blueberry. Molasses is a natural food obtained by boiling and concentrating fruit juices known to be rich in minerals such as iron, phosphorus, potassium, sodium, calcium and magnesium, and phosphoric acid, formic acid, organic acids and some vitamins. Polyphenolic compounds are natural antioxidants and are known to have protective effects against tissue damage caused by reactive oxygen species (ROS). In this study, we aimed to investigate the protective effects of grape molasses and resveratrol on ovarian damage induced by 7, 12-dimethylbenz [a] anthracene (DMBA). Methods: A total of 42 old female Wistar Albino rats, aged 18 weeks were divided into six groups. 10 mg/kg DMBA was injected in the rats in DMBA group subcutaneously on day 0 and day 7 while grape molasses feed with 20% grape molasses was given along with DMBA application to the rats in DMBA + grape molasses group. Resveratrol was administered by subcutaneous injection at 10 mg/kg/day to the DMBA + Resveratrol group, while only feed with 20% grape molasses was given to the grape molasses group. Resveratrol was administered by subcutaneous injection at 10 mg/kg/day to the resveratrol group. Results: GSH activity between the control group and molasses group, DMBA and DMBA + molasses groups and the control group and the DMBA + grape molasses groups was found statistically significant. Regarding the NO activity, the difference between the DMBA and resveratrol groups, DMBA and DMBA + resveratrol groups and the grape molasses and resveratrol groups was found statistically significant. MDA activity between DMBA + resveratrol and DMBA + grape molasses groups, and DMBA + grape molasses and grape molasses groups was found statistically significant. Conclusion: Molasses as one of the most important nutrient sources of Eastern and Central Anatolia was observed to decrease ovarian tissue oxidative damage induced with DMBA compared to resveratrol.

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