Effect of Altered Iron Metabolism on Hyperinflammation and Coagulopathy in Patients with Critical COVID-19: A Retrospective Study
Yükleniyor...
Dosyalar
Tarih
15.01.2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
JAMP
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Abstract: A novel coronavirus disease 2019 (COVID-19) outbreak has started in Wuhan, China, caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The relationship between altered iron homeostasis and
hyperinflammation may be hallmarks of COVID-19 disease. We aimed to compare some iron (ferritin and iron),
inflammation (C-reactive protein [CRP], hemoglobin, lactate dehydrogenase [LDH], neutrophil) and coagulation
(prothrombin time [PT], activated partial thromboplastin time [APTT], D-dimer, platelet) marker results of critical
COVID-19 patients with healthy controls results. In this single center retrospective study, 50 critical patients
diagnosed with COVID-19 were included, demographic, clinical characteristics, severity of disease and laboratory
test results were elicited from electronic medical records and compared to 50 healthy people. A statistically
significant increase in CRP, LDH, neutrophil, PT, APTT, D-dimer ferritin levels was observed in critical
COVID-19 patients compared with healthy people while a statistically significant decrease was observed in
hemoglobin and iron levels. In addition, no statistically significant change in platelet levels was observed.
Ferroptosis may be a significant cause of multiple organ failure in critical COVID-19 patients. Ferroptosis inhibitors
might have potential to combat ferroptosis in COVID-19. Therefore, larger studies are needed to ferroptosis in
COVID-19 in vivo and in vitro.
Açıklama
Anahtar Kelimeler
COVID-19, Ferroptosis, Hypercoagulability, Inflammation, Iron, Oxidative stress
Kaynak
International Journal of Academic Medicne and Pharmacy
WoS Q Değeri
Scopus Q Değeri
Cilt
1
Sayı
4
Künye
Önder Otlu, Mehmet Erdem, Kübranur Korkmaz, Özge Ota Gunay, Erdal İn, Tuğba Raika Kıran, Aysun Bay Karabulut. Effect of AlteredIronMetabolism on HyperinflammationandCoagulopathy in Patientswith Critical COVID-19: A RetrospectiveStudy. Int J AcadMedPharm, 2022; 4 (1): 60-64.
