Circular RNAs, miRNAs, and Exosomes: Their Roles and Importance in Amyloid-Beta and Tau Pathologies in Alzheimer's Disease

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dc.contributor.authorPala, Mukaddes
dc.contributor.authorYilmaz, Senay Gorucu
dc.date.accessioned2026-06-19T06:38:22Z
dc.date.available2026-06-19T06:38:22Z
dc.date.issued2025
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAlzheimer's disease (AD) is a devastating neurodegenerative disorder. The pathology of this disease is based on two basic mechanisms: amyloid-beta (A beta) and tau fibrillation. Many genes and mechanisms have been identified as the primary causes of AD in clinical settings, and there have been exciting developments in drug treatments. Several molecules and biological structures regulate the genome outside of the standard DNA function. As in many diseases, circular RNAs (circRNAs), microRNAs (miRNAs), and exosomes (EXOs), investigated from different aspects of AD, are useful for treatment and diagnosis. This review examines two biological elements regarding their roles in the A beta-tau pathology of AD and their potential as treatment targets. Importantly, the activities of miRNAs that play a role in these processes were evaluated.Trial Registration: ClinicalTrials.gov identifiers: NCT04120493, NCT04969172, NCT04388982
dc.identifier.doi10.1155/np/9581369
dc.identifier.issn2090-5904
dc.identifier.issn1687-5443
dc.identifier.issue1
dc.identifier.orcid0000-0003-0523-7819
dc.identifier.orcid0000-0002-0610-0526
dc.identifier.pmid40235521
dc.identifier.scopus2-s2.0-105003616726
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1155/np/9581369
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5530
dc.identifier.volume2025
dc.identifier.wosWOS:001461362800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofNeural Plasticity
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260612
dc.subjectAlzheimer'S Disease
dc.subjectCircrna
dc.subjectExosomes
dc.subjectMirna
dc.titleCircular RNAs, miRNAs, and Exosomes: Their Roles and Importance in Amyloid-Beta and Tau Pathologies in Alzheimer's Disease
dc.typeReview

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