Investigation of Optic Nerve Sheath Diameter, Intraocular Pressure, and Dry Eye in Patients with Borderline Personality Disorder: The Role of Childhood Trauma

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dc.contributor.authorSun, Tunahan
dc.contributor.authorCakar, Demet Dursun
dc.contributor.authorYesiloglu, Caner
dc.contributor.authorDemirkol, Mehmet Emin
dc.contributor.authorTamam, Lut
dc.contributor.authorUgur, Kerim
dc.contributor.authorPolat, Hatice
dc.date.accessioned2026-06-19T06:37:43Z
dc.date.available2026-06-19T06:37:43Z
dc.date.issued2025
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground/Objectives: Borderline personality disorder (BPD) is a psychiatric disorder characterized by emotional instability, impulsive behavior, and impaired interpersonal relationships. It is associated with a high prevalence of childhood trauma and neurobiological changes. This study aimed to compare ophthalmologic parameters, namely, optic nerve sheath diameter, intraocular pressure, and dry eye, in patients with BPD with healthy controls and to investigate the relations between these parameters and childhood trauma. Methods: This study included 51 female patients with BPD between the ages of 18 and 35 years, who were not using psychotropic medication, and 51 healthy controls matched for age and educational level. Optic nerve sheath diameter, intraocular pressure, and tear break-up time were measured, and trauma history was evaluated using the Childhood Trauma Questionnaire-Short Form. Independent t-test and Pearson correlation analysis were used in statistical analyses. Results: Patients with BPD were found to have significantly higher mean optic nerve sheath diameter scores (left: 3.94 +/- 0.43, right: 3.97 +/- 0.47) compared with healthy controls (left: 3.76 +/- 0.44, right: 3.78 +/- 0.45) (p < 0.05). The groups showed no significant difference in intraocular pressure and dry eye parameters (p > 0.05). A significant positive correlation was noted between emotional abuse scores and the optic nerve sheath diameter of the left eye in patients with BPD (p < 0.05; r = 0.364). Conclusions: An increased optic nerve sheath diameter may be a potential peripheral biomarker reflecting chronic stress or changes in intracranial physiology in patients with BPD. This increase is particularly associated with a history of emotional abuse. Ophthalmological parameters may contribute to understanding the neurobiological basis of BPD and serve as peripheral biomarkers or indicators of neurobiological changes.
dc.identifier.doi10.3390/jcm14165886
dc.identifier.issn2077-0383
dc.identifier.issue16
dc.identifier.orcid0000-0003-3965-7360
dc.identifier.orcid0000-0002-3131-6564
dc.identifier.orcid0000-0002-9997-351X
dc.identifier.orcid0000-0002-1383-3154
dc.identifier.orcid0000-0002-9750-7531
dc.identifier.orcid0000-0003-0444-3717
dc.identifier.orcid0000-0003-3965-7360
dc.identifier.pmid40869711
dc.identifier.scopus2-s2.0-105014429877
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/jcm14165886
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5194
dc.identifier.volume14
dc.identifier.wosWOS:001559732500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofJournal of Clinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260612
dc.subjectBorderline Personality Disorder
dc.subjectOptic Nerve Sheath Diameter
dc.subjectIntraocular Pressure
dc.subjectDry Eye
dc.subjectChildhood Trauma
dc.subjectIndicators Of Neurobiological Changes
dc.subjectBiomarkers
dc.titleInvestigation of Optic Nerve Sheath Diameter, Intraocular Pressure, and Dry Eye in Patients with Borderline Personality Disorder: The Role of Childhood Trauma
dc.typeArticle

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