Docetaxel-induced Scleroderma in A Breast Cancer Patient: A Case Report

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dc.contributor.authorKilic, Murat Ozgur
dc.contributor.authorYalaza, Metin
dc.contributor.authorBilgic, Celal Ismail
dc.contributor.authorDener, Cenap
dc.date.accessioned2025-10-24T18:10:08Z
dc.date.available2025-10-24T18:10:08Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPaclitaxel and docetaxel are antineoplastic drugs derived from the yew tree, Taxus brevifolia. They are the members of the taxane family and act by inhibiting mitotic activity due to the suppression of microtubule depolymerization. They are used in the treatment of ovarian cancer, breast cancer, gastric cancer, small cell lung cancer, and head and neck cancer. In addition to side effects such as cardiotoxicity, neutropenia, arthralgia, and myalgia, they may also cause alopecia, urticaria, mucositis, acral erythema, pustular dermatitis, erythema multiforme, and scleroderma-like mucocutaneous lesions. Scleroderma is among the uncommon side effects of taxane antineoplastic agents. As was the case in few cases in literature, it usually begins with edematous changes in the proximal aspect of the extremities, and subsequently, sclerosis is developed in the skin. Scleroderma, which usually regresses with the discontinuation of the drug and with steroid therapy, may lead to severe contractions that require physical therapy and rehabilitation in some patients. In this paper, we presented a 60-year-old female patient in whom scleroderma developed because docetaxel chemotherapy for breast cancer because it is encountered rarely.
dc.identifier.doi10.5152/tjbh.2015.1879
dc.identifier.endpage97
dc.identifier.issn2149-1976
dc.identifier.issue2
dc.identifier.pmid28331700
dc.identifier.startpage95
dc.identifier.trdizinid186517
dc.identifier.urihttps://doi.org/10.5152/tjbh.2015.1879
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/186517
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3989
dc.identifier.volume11
dc.identifier.wosWOS:000370841300009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAves
dc.relation.ispartofJournal Of Breast Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectTaxoids; scleroderma; breast cancer
dc.titleDocetaxel-induced Scleroderma in A Breast Cancer Patient: A Case Report
dc.typeArticle

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