The roles of Klotho and FGF-23 in bipolar manic episode

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dc.authoridKazgan Kilicaslan, Asli/0000-0002-0312-0476
dc.contributor.authorEmir, B. Sirlier
dc.contributor.authorYildiz, S.
dc.contributor.authorKilicaslan, A. Kazgan
dc.contributor.authorKilic, F.
dc.contributor.authorUgur, K.
dc.contributor.authorAydin, S.
dc.contributor.authorAtmaca, M.
dc.date.accessioned2025-10-24T18:10:33Z
dc.date.available2025-10-24T18:10:33Z
dc.date.issued2023
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractOBJECTIVE: Bipolar disorder (manic episode) is an essential psychiatric disorder with unknown etiology, in which inflammation is considered to play a role. Klotho and FGF-23 are known to be associated with inflammation. Therefore, this study aimed to determine the link between Klotho and FGF-23 levels and bipolar disorder. PATIENTS AND METHODS: In this study, 42 men with BD and 41 healthy controls were enrolled, followed up, and/or treated at the High-Security Forensic Psychiatry Clinic. Sociodemographic data form, Young Mania Rating Scale, and Hamilton Depression Rating Scale were applied to all participants. RESULTS: Klotho and FGF-23 levels were significantly increased in patients with BD manic episodes. There was no correlation between Klotho and FGF-23 levels and clinical parameters. For Klotho and FGF-23, cutoff values of 69 and 1,646 yielded 67.4% sensitivity and 72.1% specificity and 81.4% sensitivity and 51.2% specificity, respectively. CONCLUSIONS: Klotho and FGF-23 may play critical roles in the etiopathology of manic episodes and are potential candidate biomarkers for bipolar disorder. This relationship might contribute to the etiopathogenesis of the disease and determine its treatment. Anti-Klotho and anti-FGF-23 administration may be a future treatment for controlling the course of the disease.
dc.identifier.endpage108
dc.identifier.issn1128-3602
dc.identifier.pmid37869955
dc.identifier.startpage101
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4256
dc.identifier.volume27
dc.identifier.wosWOS:001091509100015
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectBipolar disorder; Inflammation; Klotho; FGF-23
dc.titleThe roles of Klotho and FGF-23 in bipolar manic episode
dc.typeArticle

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