Association of HIF1α, BNIP3, and BNIP3L with Hypoxia-Related Metabolic Stress in Metabolic Syndrome

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dc.contributor.authorKiran, Tugba Raika
dc.contributor.authorKeskin, Lezan
dc.contributor.authorErdem, Mehmet
dc.contributor.authorGuctekin, Zeynep
dc.contributor.authorInceoglu, Feyza
dc.date.accessioned2026-06-19T06:37:41Z
dc.date.available2026-06-19T06:37:41Z
dc.date.issued2026
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground and Objectives: Metabolic syndrome (MetS) is a complex condition marked by insulin resistance, central obesity, dyslipidemia, and chronic inflammation. Emerging evidence highlights the roles of hypoxia and mitochondrial stress in its pathophysiology. Hypoxia-inducible factor-1 alpha (HIF1 alpha) and the mitophagy-associated proteins BNIP3 and BNIP3L are key components of hypoxia-responsive mitochondrial stress signaling. This study aimed to evaluate the circulating levels of HIF1 alpha, BNIP3, and BNIP3L in MetS and to explore their associations with metabolic and inflammatory parameters. Materials and Methods: Serum concentrations of HIF1 alpha, BNIP3, and BNIP3L were measured by ELISA in 40 patients with MetS and 40 age and sex-matched controls. Biochemical, hematological, and anthropometric parameters were assessed, and receiver operating characteristic (ROC) analyses were performed to evaluate diagnostic performance. Results: Serum levels of HIF1 alpha, BNIP3, and BNIP3L levels were significantly higher in MetS patients compared with controls (p = 0.001). ROC analysis demonstrated strong diagnostic potential, particularly for BNIP3 (AUC = 0.928), followed by HIF1 alpha (AUC = 0.885) and BNIP3L (AUC = 0.770). These markers showed significant associations with metabolic indicators such as BMI, fasting glucose, triglycerides, and inflammatory markers. Conclusions: The coordinated upregulation of circulating HIF1 alpha, BNIP3, and BNIP3L in MetS is associated with metabolic dysregulation and systemic inflammation, reflecting alterations in hypoxia-responsive mitophagy-associated signaling rather than direct functional impairment of mitophagy. These findings support the potential relevance of these markers as indicators of metabolic stress in MetS. Further tissue-based and mechanistic studies are warranted to clarify their role in disease pathophysiology.
dc.identifier.doi10.3390/medicina62010166
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue1
dc.identifier.pmid41597451
dc.identifier.scopus2-s2.0-105028779428
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/medicina62010166
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5168
dc.identifier.volume62
dc.identifier.wosWOS:001670919600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMedicina-Lithuania
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260612
dc.subjectMetabolic Syndrome
dc.subjectHif1 Alpha
dc.subjectBnip3
dc.subjectBnip3L
dc.subjectHypoxia
dc.subjectMitophagy
dc.subjectMitophagy-Related Signaling
dc.subjectMetabolic Stress
dc.titleAssociation of HIF1α, BNIP3, and BNIP3L with Hypoxia-Related Metabolic Stress in Metabolic Syndrome
dc.typeArticle

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