Effects of long-term heat stress and dietary restriction on the expression of genes of steroidogenic pathway and small heat-shock proteins in rat testicular tissue

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dc.authoridKAYIS, Seyit Ali/0000-0003-4791-8946|YILDIRIM, MEHMET/0000-0003-4768-4537|atli, mehmet/0000-0001-9853-5334|Yilmaz, Rahsan/0000-0002-0944-2230;
dc.contributor.authorBozkaya, F.
dc.contributor.authorAtli, M. O.
dc.contributor.authorGuzeloglu, A.
dc.contributor.authorKayis, S. A.
dc.contributor.authorYildirim, M. E.
dc.contributor.authorKurar, E.
dc.contributor.authorYilmaz, R.
dc.date.accessioned2025-10-24T18:09:22Z
dc.date.available2025-10-24T18:09:22Z
dc.date.issued2017
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThe aim was to investigate the effects of long-term heat stress and dietary restriction on the expression of certain genes involving in steroidogenic pathway and small heat-shock proteins (sHSPs) in rat testis. Sprague Dawley rats (n = 24) were equally divided into four groups. Group I and II were kept at an ambient temperature of 22 degrees C, while Groups III and IV were reared at 38 degrees C for 9 weeks. Feed was freely available for Group I and Group III, while Group II and Group IV were fed 60% of the diet consumed by their ad libitum counterparts. At the end of 9 weeks, testicles were collected under euthanasia. Total RNA was isolated from testis tissue samples. Expression profiles of the genes encoding androgen-binding protein, follicle-stimulating hormone receptor, androgen receptor, luteinising hormone receptor, steroidogenic acute regulatory protein (StAR), cyclooxygenase-2 and sHSP genes were assessed at mRNA levels using qPCR. Long-term heat stress decreased the expression of StAR and HspB10 genes while dietary restriction upregulated StAR gene expression. The results suggested that long-term heat stress negatively affected the expression of StAR and HspB10 genes and the dietary restriction was able to reverse negative effect of heat stress on the expression of StAR gene in rat testis.
dc.description.sponsorshipHarran University Scientific Research Council [12035]
dc.description.sponsorshipThis study received financial support of Harran University Scientific Research Council (Grant No: 12035).
dc.identifier.doi10.1111/and.12668
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue6
dc.identifier.pmid27659778
dc.identifier.scopus2-s2.0-84988908526
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/and.12668
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3604
dc.identifier.volume49
dc.identifier.wosWOS:000408624600005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectdietary restriction; heat stress; sHSP; steroidogenesis
dc.titleEffects of long-term heat stress and dietary restriction on the expression of genes of steroidogenic pathway and small heat-shock proteins in rat testicular tissue
dc.typeArticle

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