AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation

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dc.contributor.authorCicek, Betul
dc.contributor.authorHacimuftuoglu, Ahmet
dc.contributor.authorYeni, Yesim
dc.contributor.authorKuzucu, Mehmet
dc.contributor.authorGenc, Sidika
dc.contributor.authorCetin, Ahmet
dc.contributor.authorTaghizadehghalehjoughi, Ali
dc.date.accessioned2026-06-19T06:39:57Z
dc.date.available2026-06-19T06:39:57Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThe present study was designed to evaluate whether AuNPs (gold nanoparticles) synthesized with the Cynara scolymus (CS) leaf exert protective and/or alleviative effects on arsenic (As)-induced hippocampal neurotoxicity in mice. Neurotoxicity in mice was developed by orally treating 10 mg/kg/day sodium arsenite (NaAsO2) for 21 days. 10 mu g/g AuNPs, 1.6 g/kg CS, and 10 mu g/g CS-AuNPs were administered orally simultaneously with 10 mg/ kg As. CS and CS-AuNPs treatments showed down-regulation of TNF-alpha and IL-1 beta levels. CS and CS-AuNPs also ameliorated apoptosis and reduced the alterations in the expression levels of D1 and D2 dopamine receptors induced by As. Simultaneous treatment with CS and CS-AuNPs improved As-induced learning, memory deficits, and motor coordination in mice assessed by water maze and locomotor tests, respectively. The results of this study provide evidence that CS-AuNPs demonstrated neuroprotective roles with antioxidant, anti-inflammatory, and anti-apoptotic effects, as well as improving D1 and D2 signaling, and eventually reversed neurobehavioral impairments.
dc.description.sponsorshipEuropean Union 's Horizon Europe framework program project 'European Partnership for the Assessment of Risks from Chemicals (PARC)
dc.description.sponsorshipThe present study was partly funded by the European Union 's Horizon Europe framework program project 'European Partnership for the Assessment of Risks from Chemicals (PARC) .
dc.identifier.doi10.1016/j.etap.2024.104417
dc.identifier.issn1382-6689
dc.identifier.issn1872-7077
dc.identifier.orcid0000-0003-3824-2462
dc.identifier.orcid0009-0000-5536-5013
dc.identifier.orcid0000-0002-5510-6852
dc.identifier.pmid38493879
dc.identifier.scopus2-s2.0-85189019729
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.etap.2024.104417
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5877
dc.identifier.volume107
dc.identifier.wosWOS:001223389200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofEnvironmental Toxicology and Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260612
dc.subjectAunps
dc.subjectArsenic
dc.subjectCynara Scolymus
dc.subjectNeurotoxicity
dc.subjectD1R
dc.subjectD2R
dc.titleAuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation
dc.typeArticle

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