Investigating the anti-tumoral effect of yarrow (Achillea milllefolium) on the mice in which ehrlich solid tumor is created

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dc.contributor.authorUzun, Gokce Bagci
dc.contributor.authorNisari, Mehtap
dc.contributor.authorYay, Arzu Hanim
dc.contributor.authorKaratoprak, Gokce Seker
dc.contributor.authorAl, Ozge
dc.contributor.authorUcar, Sumeyye
dc.contributor.authorArslan, Ayla
dc.date.accessioned2026-06-19T06:41:03Z
dc.date.available2026-06-19T06:41:03Z
dc.date.issued2022
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description2nd International Congress on Sports, Anthropology, Nutrition, Anatomy and Radiology -- JUL 20-23, 2020 -- Nevsehir, TURKEY
dc.description.abstractIn this study, BALB/c mice with Ehrlich solid tumors were used to examine the effect of Achillea millefolium L. (AM) extract on the Ehrlich ascites tumor (EAT) model, which is one of the experimental cancer models. Also known as yarrow and plant, AM has antioxidant, anti-inflammatory, antibacterial and antitumor properties. In our study, 57 male BALB/c type mice, 8-10 weeks old, weighing 25-30 g, were used. Mice were divided into two groups. Ehrlich Solid Tumor group: Negative Control Group (ENC), Positive Control Group (EPC), and Treatment Group (TG) (TNCAM-200 mg/kg, TPCAM-400 mg/kg). EPC and TG were given to EAT cells. Each EAT contained 1 x 106 (will be 6 out of 10: so:000000) EAT cells, 0.1 ml of phosphate-buffered saline (PBS) was administered subcutaneously (s.c.) to the nape of mice. Then It was awaited for solid tumor formation. AM extract was administered intraperitoneally (i.p.) to TG for 17 days to mice. AM extract was found to have a curative effect on areas of inflammation, bleeding, and necrosis in treatment groups treated with AM extract alone. The treatment groups showed nearly normal histological results compared to the positive control group. According to the results, the TPCAM-400 mg/kg group had a more significant histological impact than the TNCAM-200 mg/kg group. In terms of tumor growth, tumor length, tumor volume, and tumor weight, AM extract did not show significant effects. However, in the light of histological findings, promising results of AM were observed in mice in which Ehrlich Solid Tumor was formed.
dc.description.sponsorshipErciyes University Scientific Research Projects Coordination Unit
dc.description.sponsorshipThis research was produced from Goekce BAGCI UZUN's Ph.D. thesis named Investigation Of The Antitumoral Effect Of On Ehrlich Solid Tumor-Formed Mice Of Yarrow (Achilea Milllefolium) is created. The financial source of this research was funded by Erciyes University Scientific Research Projects Coordination Unit.
dc.identifier.doi10.1007/s12032-022-01917-3
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.issue1
dc.identifier.orcid0000-0003-4992-6915
dc.identifier.orcid0000-0001-5829-6914
dc.identifier.orcid0000-0002-0541-8372
dc.identifier.orcid0000-0001-5859-7784
dc.identifier.orcid0000-0001-5292-3593
dc.identifier.orcid0000-0003-3378-3745
dc.identifier.pmid36472705
dc.identifier.scopus2-s2.0-85143407927
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s12032-022-01917-3
dc.identifier.urihttps://hdl.handle.net/20.500.12899/6028
dc.identifier.volume40
dc.identifier.wosWOS:000895398300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofMedical Oncology
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260612
dc.subjectEhrlich Solid Tumor
dc.subjectYarrow
dc.subjectAntitumoral
dc.titleInvestigating the anti-tumoral effect of yarrow (Achillea milllefolium) on the mice in which ehrlich solid tumor is created
dc.typeConference Object

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