Trimetazidine has protective effects on spermatogenesis in a streptozotocin-induced diabetic rat model

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dc.authoridaltintas, ramazan/0000-0003-3145-3005|Akbulut, Ziya/0000-0001-7146-4767|Ozcan, Muhammet/0000-0002-9809-7204|HEKIMOGLU, RUMEYSA HEKIMOGLU/0000-0003-4300-7213
dc.contributor.authorOzcan, M. F.
dc.contributor.authorHekimoglu, E. R.
dc.contributor.authorEner, K.
dc.contributor.authorNamuslu, M.
dc.contributor.authorAltintas, R.
dc.contributor.authorCelik, H. T.
dc.contributor.authorAkbulut, Z.
dc.date.accessioned2025-10-24T18:09:22Z
dc.date.available2025-10-24T18:09:22Z
dc.date.issued2017
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThe aim of this study was to investigate the protective effects of trimetazidine (TMZ), as an antioxidant agent, on streptozotocin (STZ)-induced diabetic rats. A total of 50 male Sprague Dawley rats were randomly classified into five groups as follows: Group 1 (control), Group 2 (STZ-induced diabetic rats), Group 3 (STZ-induced diabetic rats treated orally with 1cc/day isotonic saline), Group 4 (diabetic rats treated orally with 10mg/kg/day TMZ) and Group 5 (diabetic rats treated orally with 20mg/kg/day TMZ). After 8weeks, orchiectomy was carried out. Histopathological and electron microscopic examinations were performed in all groups. In groups 1 and 5, the structural and ultra-structural findings of the testicular tissue and spermatogenesis were found normal. In groups 2, 3 and 4, similar results were obtained in terms of the impaired testicular architecture and degeneration of spermatogenesis. The administration of an optimal dose of TMZ protects against the harmful effects of diabetes mellitus on spermatogenesis in rats. TMZ therapy can be used to maintain normal spermatogenesis in diabetic rats.
dc.identifier.doi10.1111/and.12780
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue10
dc.identifier.pmid28261829
dc.identifier.scopus2-s2.0-85014453739
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/and.12780
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3605
dc.identifier.volume49
dc.identifier.wosWOS:000414965200023
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectdiabetes; rats; spermatogenesis; streptozotocin; trimetazidine
dc.titleTrimetazidine has protective effects on spermatogenesis in a streptozotocin-induced diabetic rat model
dc.typeArticle

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