Galectin-3: A biochemical marker to detect paroxysmal atrial fibrillation?

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dc.contributor.authorSelcoki, Yusuf
dc.contributor.authorAydin, H. Ibrahim
dc.contributor.authorCelik, Tugrul H.
dc.contributor.authorIsleyen, Ahmet
dc.contributor.authorErayman, Ali
dc.contributor.authorDemircelik, M. Bora
dc.contributor.authorDemirin, Hilmi
dc.date.accessioned2025-10-24T18:10:32Z
dc.date.available2025-10-24T18:10:32Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurpose: Atrial fibrillation (AF) is the most common form of arrhythmia. AF leads to electrical remodelling and fibrosis of the atria; however, the mechanism(s) remain poorly understood. Galectin-3 is a potential mediator of cardiac fibrosis. The present study aimed to examine the relationship between serum galectin-3 levels and paroxysmal AF. Methods: Forty-six patients with paroxysmal AF and preserved left ventricular systolic function, and 38 age-and gender-matched control subjects, were involved in the study. Serum galectin-3 levels were analyzed with an enzyme-linked immunosorbent assay (ELISA). Results: Serum galectin-3 levels (median 1.38 ng/mL; 1.21 ng/mL-1.87 ng/mL; p < 0.001) were significantly elevated in patients with paroxysmal AF compared with the control. Left atrial diameter was significantly higher in patients with paroxysmal AF (41.2 +/- 3.0 mm vs. 39.6 +/- 3.3 mm). Left atrial diameter was found to be significantly correlated with serum galectin-3 levels in patients with paroxysmal AF (r= 0.378, p = 0.001). Conclusion: Serum galectin-3 levels are significantly elevated and significantly correlated with left atrial diameter in patients with paroxysmal AF.
dc.identifier.endpageS202
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue6
dc.identifier.pmid27917818
dc.identifier.scopus2-s2.0-85047586594
dc.identifier.scopusqualityQ2
dc.identifier.startpageS197
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4238
dc.identifier.volume39
dc.identifier.wosWOS:000389725000038
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCanadian Soc Clinical Investigation
dc.relation.ispartofClinical And Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectHeart-Failure; Fibrosis; Mechanisms; Risk; Community; Disease
dc.titleGalectin-3: A biochemical marker to detect paroxysmal atrial fibrillation?
dc.typeArticle

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