Manufacturing of chitosan based drug release systems from tamarind shells for long-term and effective methylprednisolone sodium succinate release
Küçük Resim Yok
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Natl Inst Science Communication-Niscair
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study a microparticular drug delivery system containing tamarind shell and chitosan has been developed to realize the controlled release of methylprednisolone sodium succinate an important corticosteroid. Drug-loaded tamarind shells are coated with chitosan for a pH-controlled release. The release kinetics of the system have been examined in detail at three different pH ranges (3, 5 and 7.4). In our pH sensitive release systems a slow release up to 39.02%+/- 0.81 at pH=7.4 at 72 hours. But we see that there is a faster release at 70.58 +/- 1.73% at pH=5 and 96.68 +/- 1.70% at pH=3 in 72 hours. Rapid release in acidic media depends on the solubility of the chitosan structure in acidic environments. It is believed that the pH sensitive carrier system obtained within the scope of the study will have a high potential for use in many biomedical application areas (wound surface application, etc.).
Açıklama
Anahtar Kelimeler
Chitosan, Drug Delivery Systems, Methylprednisolone Sodium Succinate, Tamarind Shell Particles
Kaynak
Indian Journal of Chemical Technology
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
29
Sayı
3
