Manufacturing of chitosan based drug release systems from tamarind shells for long-term and effective methylprednisolone sodium succinate release

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dc.contributor.authorAcari, Idil Karaca
dc.date.accessioned2026-06-19T06:41:21Z
dc.date.available2026-06-19T06:41:21Z
dc.date.issued2022
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractIn this study a microparticular drug delivery system containing tamarind shell and chitosan has been developed to realize the controlled release of methylprednisolone sodium succinate an important corticosteroid. Drug-loaded tamarind shells are coated with chitosan for a pH-controlled release. The release kinetics of the system have been examined in detail at three different pH ranges (3, 5 and 7.4). In our pH sensitive release systems a slow release up to 39.02%+/- 0.81 at pH=7.4 at 72 hours. But we see that there is a faster release at 70.58 +/- 1.73% at pH=5 and 96.68 +/- 1.70% at pH=3 in 72 hours. Rapid release in acidic media depends on the solubility of the chitosan structure in acidic environments. It is believed that the pH sensitive carrier system obtained within the scope of the study will have a high potential for use in many biomedical application areas (wound surface application, etc.).
dc.identifier.endpage250
dc.identifier.issn0971-457X
dc.identifier.issn0975-0991
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85134610324
dc.identifier.scopusqualityQ4
dc.identifier.startpage240
dc.identifier.urihttps://hdl.handle.net/20.500.12899/6205
dc.identifier.volume29
dc.identifier.wosWOS:000863101000002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAcari, Idil Karaca
dc.language.isoen
dc.publisherNatl Inst Science Communication-Niscair
dc.relation.ispartofIndian Journal of Chemical Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260612
dc.subjectChitosan
dc.subjectDrug Delivery Systems
dc.subjectMethylprednisolone Sodium Succinate
dc.subjectTamarind Shell Particles
dc.titleManufacturing of chitosan based drug release systems from tamarind shells for long-term and effective methylprednisolone sodium succinate release
dc.typeArticle

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