Obesity as a modifying factor of periodontal therapy outcomes: local and systemic adipocytokines and oxidative stress markers

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dc.authoridtoy, vesile elif/0000-0001-5183-6295|Ataoglu, Tamer/0000-0003-1937-0290;
dc.contributor.authorToy, Vesile Elif
dc.contributor.authorAtaoglu, Tamer
dc.contributor.authorEltas, Abubekir
dc.contributor.authorOtlu, Husniye Gul
dc.contributor.authorKarabulut, Aysun Bay
dc.date.accessioned2025-10-24T18:08:49Z
dc.date.available2025-10-24T18:08:49Z
dc.date.issued2023
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjectives Adipocytokines and oxidative stress (OS) are involved in the pathogenesis of both obesity and periodontitis. The aim of this study was to evaluate periodontal therapy outcomes in terms of serum and gingival crevicular fluid (GCF) levels of adipocytokines and OS markers in obese patients with periodontitis, in order to have an insight into the association between obesity and periodontitis.Materials and methods A total of 39 patients (20 obese, 19 non-obese) with periodontitis were included in this study. Clinical periodontal parameters were assessed; serum and GCF levels of adipocytokines and OS markers were evaluated by ELISA at baseline and 3 months after non-surgical periodontal therapy.Results Significant improvements in clinical periodontal parameters were observed in both groups at 3 months (p < 0.01). While serum levels of TNF-alpha, leptin, and total oxidant status (TOS) in the obese group were higher at baseline (p < 0.01), leptin levels remained higher at 3 months despite a significant decrease (p < 0.01). Although NSPT improved GCF levels of total antioxidant status (TAS) and TOS in both groups, they were significantly different between the groups after therapy (p < 0.05).Conclusions It seems that leptin, TNF-alpha, and TOS contribute to systemic inflammatory and oxidative state in patients with obesity. Despite improvements in clinical periodontal parameters, obesity might be a modulating factor in the development and progression of periodontal disease in terms of some adipocytokines and OS markers.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [114S823]
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK), (Project number 114S823).
dc.identifier.doi10.1007/s00784-022-04854-7
dc.identifier.endpage2773
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue6
dc.identifier.pmid36604342
dc.identifier.startpage2763
dc.identifier.urihttps://doi.org/10.1007/s00784-022-04854-7
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3323
dc.identifier.volume27
dc.identifier.wosWOS:000909185400002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofClinical Oral Investigations
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectAdipocytokine; Non-surgical periodontal therapy; Obesity; Oxidative stress
dc.titleObesity as a modifying factor of periodontal therapy outcomes: local and systemic adipocytokines and oxidative stress markers
dc.typeArticle

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