Ameliorative effect of selenium in cisplatin-induced testicular damage in rats

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dc.authoridYILDIRIM, MEHMET/0000-0003-4768-4537|Karadeniz, Ali/0000-0002-0976-9380
dc.contributor.authorSimsek, Nejdet
dc.contributor.authorKoc, Akif
dc.contributor.authorKaradeniz, Ali
dc.contributor.authorYildirim, Mehmet Erol
dc.contributor.authorCelik, Huseyin Tugrul
dc.contributor.authorSari, Erhan
dc.contributor.authorKara, Adem
dc.date.accessioned2025-10-24T18:08:54Z
dc.date.available2025-10-24T18:08:54Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractIn this study, we investigated the protective effect of selenium (Se) on cisplatin (Cis) induced testicular damage using histopathological, immunohistochemical and biochemical approaches. Twenty-one male Wistar rats were equally divided into three groups of seven rats each: control (C), Cis, and Cis + Se. Cis and Cis + Se group rats received Cis at a dose of 12 mg/kg b.w./day, intraperitoneally for 3 consecutive days. Cis + Se group rats received selenium via oral gavage 3 mg/kg/day (twice-a day as 1.5 mg/kg) until 11th consecutive days starting at 5 days before cisplatin injection. C group received only 0.9% NaCl intraperitoneally and orally at same time and at equal volume. After the treatment, the histopathological, immunohistochemical and biochemical examinations were performed. In seminiferous tubules of Cis treated rats were observed the most consistent findings characterized with vacuolization, desquamation, disorganization, and also was a considerable reduction in elongated spermatids, however the Cis + Se group exhibited improved histopathologic changes. In the immunohistochemical examinations, caspase-3 immunopositive cells displayed higher in the Cis group according to C and Cis + Se groups. Bcl-2 and NF-kappa B staining revealed a moderate number in the C group and significantly fewer in the Cis group compared to the Cis + Se groups. Additionally, MDA levels were also significantly increased in the Cis group in comparison to Control group, but pretreatment with selenium prevented elevation of MDA levels significantly in Cis + Se group rats. This study indicates that Cis-treatment induced testicular apoptosis and lipid peroxidation, and combined treatment with selenium prevented severity of the toxicity in rats. (C) 2016 Elsevier GmbH. All rights reserved.
dc.identifier.doi10.1016/j.acthis.2016.02.002
dc.identifier.endpage270
dc.identifier.issn0065-1281
dc.identifier.issn1618-0372
dc.identifier.issue3
dc.identifier.pmid26920108
dc.identifier.scopus2-s2.0-84961775489
dc.identifier.scopusqualityQ2
dc.identifier.startpage263
dc.identifier.urihttps://doi.org/10.1016/j.acthis.2016.02.002
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3367
dc.identifier.volume118
dc.identifier.wosWOS:000374425300009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Gmbh
dc.relation.ispartofActa Histochemica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectAntineoplastic agents; Trace elements; Apoptosis; Lipid peroxidation
dc.titleAmeliorative effect of selenium in cisplatin-induced testicular damage in rats
dc.typeArticle

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