Neuroprotective Effects of Pregabalin Against Spinal Cord Ischemia-Reperfusion Injury in Rats

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dc.authoridOzdogan, Selcuk/0000-0003-1711-5771
dc.contributor.authorKazanci, Burak
dc.contributor.authorOzdogan, Selcuk
dc.contributor.authorKahveci, Ramazan
dc.contributor.authorGokce, Emre Cemal
dc.contributor.authorYigitkanli, Kazim
dc.contributor.authorGokce, Aysun
dc.contributor.authorErdogan, Bulent
dc.date.accessioned2025-10-24T18:10:03Z
dc.date.available2025-10-24T18:10:03Z
dc.date.issued2017
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAIM: To evaluate the effect of pregabalin pre-treatment on spinal cord ischemia-reperfusion (I/R) injury and compare with methylprednisolone (MP). MATERIAL and METHODS: Thirty-two rats were randomly divided into four groups as follow: Group 1 (sham)(n= 8), group 2 (ischemia only)(n= 8), group 3 (30 mg/kg pregabalin)(n= 8), and group 4 (30 mg/kg methylprednisolone)(n= 8). Laparotomy was performed without aortic clamp in the sham group. All animals were sacrificed 24 hours after surgery. The spinal cord tissue samples were harvested and caspase-3 activity, tumor necrosis factor-alpha (TNF-alpha) and Interleukin-1 Beta (IL-1 beta) levels, catalase (CAT) activity, glutathione peroxidase (GPx) activity, superoxide dismutase (SOD) levels malondialdehyde (MDA) levels and nitric oxide (NO) levels were analyzed to investigate the effects of different excitatory and inflammatory pathways in mechanism of I/R injury. Ultrastructural and histopathological examinations were carried out. Neurological recovery was measured by Basso, Beattie, Bresnahan (BBB) test and Inclined Plane Test. RESULTS: Decresead caspase-3 activity and decreased inflammatory markers like TNF-alpha, IL-1 beta, and decresaed excitotatory pathways like CAT, GPx, MDA, NO and SOD were observed in both pregabalin pre-treatment and MP treatment groups. Pregabalin pre-treatment produced better ultrastructural results compared to MP treatment, as with histopathological examination. Pregabalin group showed better recovery compared to MP treament group according to BBB scoring system. CONCLUSION: Pregabalin pre-treatmet and MP treatment both has neuroprotective effect on I/R injury by decreasing caspase dependant apoptosis, and inflammatory and oxidative stress markers. In addition, pregabalin pre-treatment had better clinical effects compared to MP treatment.
dc.identifier.doi10.5137/1019-5149.JTN.17959-16.1
dc.identifier.endpage961
dc.identifier.issn1019-5149
dc.identifier.issue6
dc.identifier.pmid27476927
dc.identifier.scopus2-s2.0-85032578111
dc.identifier.scopusqualityQ3
dc.identifier.startpage952
dc.identifier.trdizinid273510
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.17959-16.1
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/273510
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3960
dc.identifier.volume27
dc.identifier.wosWOS:000417623700015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTurkish Neurosurgical Soc
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectPregabalin; Methylprednisolone; Spinal cord injury; Neuroprotection
dc.titleNeuroprotective Effects of Pregabalin Against Spinal Cord Ischemia-Reperfusion Injury in Rats
dc.typeArticle

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