Sinovac vaccination and the course of COVID-19 disease in hospitalized patients in Turkey

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dc.authorid0000-0003-1025-7662en_US
dc.contributor.authorAcun Delen, Leman
dc.contributor.authorÖterkuş, Mesut
dc.date.accessioned2022-07-26T06:34:51Z
dc.date.available2022-07-26T06:34:51Z
dc.date.issued2022en_US
dc.departmentMTÖ Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionReceived30 October 2021, Accepted16 December 2021, Published online2 June 2022.en_US
dc.descriptionCopyright © 2022, Annals of Saudi Medicine, Saudi Arabia. This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND). The details of which can be accessed at http://creativecommons. org/licenses/by-nc-nd/4.0/en_US
dc.descriptionDelen, Leman Acuna, Department of Anesthesiology and Reanimation, Malatya Education and Research Hospital, Malatya, Turkey. Mesut Örtekus, Department of Anesthesiology and Reanimation, Malatya Turgut Özal University, Malatya, Turkey.en_US
dc.description.abstractBACKGROUND: The Alpha variant of SARS-CoV-2 has a higher transmission rate than the first variant identified. The efficacy of vaccines is affected by the characteristics of SARS-CoV-2 variants. OBJECTIVE: Investigate the relationship of vaccination and virus variant on the course of the disease in patients who were hospitalized with a diagnosis of COVID-19. DESIGN: Retrospective, cohort study SETTING: Tertiary health institution PATIENTS AND METHODS: The study included patients older than the age of 18 years who were hospitalized in a COVID-19 service or the intensive care unit with a diagnosis of COVID-19 between 1 January 2021 and 30 April 2021. Demographic characteristics, vaccination and the Alpha virus variant status, comorbidities, and information about hospitalization were obtained from the hospital automation system and patient files. MAIN OUTCOME MEASURES: Vaccination rate and relationship with course of disease. SAMPLE SIZE: 608 RESULTS: Most of the patients (n=482, 79.3%) were admitted to the COVID-19 service. More of the COVID-19 service patients had the Alpha variant than the patients admitted to ICU (P<.009). The Alpha variant was also more common in younger patients (P<.001). There was no relationship between the Alpha virus and comorbid diseases such as diabetes mellitus and hypertension. Mortality was lower in the patients who had received a second dose of the Sinovac vaccine (P=.004) compared with unvaccinated patients. CONCLUSION: Although the Alpha variant spreads faster, it has a milder course. If only the Sinovac vaccine is available, we recommend that the two doses of the Sinovac vaccine be administered. LIMITATIONS: Our study is single-center and did not include pregnant and pediatric patients. CONFLICT OF INTEREST: None.en_US
dc.identifier.citationDelen, L. A., & Örtekus, M. (2022). Sinovac vaccination and the course of COVID-19 disease in hospitalized patients in Turkey. Annals of Saudi Medicine, 42(3), 147-154.en_US
dc.identifier.doi10.5144/0256-4947.2022.147
dc.identifier.endpage154en_US
dc.identifier.issn0256-4947en_US
dc.identifier.issue3en_US
dc.identifier.pmid35658583
dc.identifier.scopus2-s2.0-85131702487en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage147en_US
dc.identifier.urihttps://doi.org/10.5144/0256-4947.2022.147
dc.identifier.uri1319-9226
dc.identifier.urihttps://hdl.handle.net/20.500.12899/1181
dc.identifier.volume42en_US
dc.identifier.wosWOS:000811297700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖterkuş, Mesut
dc.language.isoenen_US
dc.publisherKing Faisal Specialist Hospital and Research Centreen_US
dc.relation.ispartofAnnals of Saudi Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleSinovac vaccination and the course of COVID-19 disease in hospitalized patients in Turkeyen_US
dc.typeArticleen_US

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