A study about excellent xanthine oxidase inhibitory effects of new pyridine salts

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Küçük Resim

Tarih

2021

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Springer

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

A series of pyridine salts were synthesized containing vitamin B3 (niacin), isonicotinonitrile, and non-substituted pyridine fragment from reactions of 1,3-dibromopropane, 1,4-dibromobutane, and 4,4?-bis(chloromethyl)-1,1?-biphenyl reactants with pyridines. The builds of pyridine salts were identified by dint of IR, 1H, and 13C NMR spectroscopic techniques, and CHN analyses. Therewithal, the build of a compound was assigned via the X-ray single-crystal diffraction method. 1,3-Bis(3-cyanopyridine-1-ium-1-yl)propane dibromide crystallizes in the orthorhombic space group Ccce, with half of the cation molecule and one bromide anion in the asymmetric unit. Enzyme inhibitory properties of pyridine compounds were tested on the activities of xanthine oxidase (XO) and determined in the range from 0.394 to 0.623 ?M. All of the compounds inhibited enzyme more effectively than allopurinol that which is a standard drug. In addition, docking calculations were applied to investigate the binding properties and interactions of pyridine salts towards XO.

Açıklama

Anahtar Kelimeler

Pyridine salt, Xanthine oxidase, Molecular docking, Crystal structure, Enzyme inhibition

Kaynak

Monatshefte fur Chemie

WoS Q Değeri

Q4

Scopus Q Değeri

Q3

Cilt

Sayı

Künye

Yılmaz, Ü., Noma, S. A. A., Taşkın Tok, T., Şen, B., Gök, Y., Aktaş, A., ... & Aygün, M. (2021). A study about excellent xanthine oxidase inhibitory effects of new pyridine salts. Monatshefte für Chemie-Chemical Monthly, 1-10.