A study about excellent xanthine oxidase inhibitory effects of new pyridine salts

Basit Öğe Kaydı
dc.authorid0000-0002-2806-4781en_US
dc.contributor.authorYılmaz, Ülkü
dc.contributor.authorNoma, Samir Abbas Ali
dc.contributor.authorTaşkın Tok, Tuğba
dc.contributor.authorŞen, Betül
dc.contributor.authorGök, Yetkin
dc.contributor.authorAktaş, Aydın
dc.contributor.authorAteş, Burhan
dc.contributor.authorAygün, Muhittin
dc.date.accessioned2021-09-05T17:20:23Z
dc.date.available2021-09-05T17:20:23Z
dc.date.issued2021en_US
dc.departmentMTÖ Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Mühendislik Temel Bilimleri Bölümüen_US
dc.description.abstractA series of pyridine salts were synthesized containing vitamin B3 (niacin), isonicotinonitrile, and non-substituted pyridine fragment from reactions of 1,3-dibromopropane, 1,4-dibromobutane, and 4,4?-bis(chloromethyl)-1,1?-biphenyl reactants with pyridines. The builds of pyridine salts were identified by dint of IR, 1H, and 13C NMR spectroscopic techniques, and CHN analyses. Therewithal, the build of a compound was assigned via the X-ray single-crystal diffraction method. 1,3-Bis(3-cyanopyridine-1-ium-1-yl)propane dibromide crystallizes in the orthorhombic space group Ccce, with half of the cation molecule and one bromide anion in the asymmetric unit. Enzyme inhibitory properties of pyridine compounds were tested on the activities of xanthine oxidase (XO) and determined in the range from 0.394 to 0.623 ?M. All of the compounds inhibited enzyme more effectively than allopurinol that which is a standard drug. In addition, docking calculations were applied to investigate the binding properties and interactions of pyridine salts towards XO.en_US
dc.identifier.citationYılmaz, Ü., Noma, S. A. A., Taşkın Tok, T., Şen, B., Gök, Y., Aktaş, A., ... & Aygün, M. (2021). A study about excellent xanthine oxidase inhibitory effects of new pyridine salts. Monatshefte für Chemie-Chemical Monthly, 1-10.en_US
dc.identifier.doi10.1007/s00706-021-02831-6
dc.identifier.endpage10en_US
dc.identifier.issn0026-9247en_US
dc.identifier.issn1434-4475en_US
dc.identifier.scopus2-s2.0-85113295173en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1007/s00706-021-02831-6
dc.identifier.urihttps://hdl.handle.net/20.500.12899/388
dc.identifier.wosWOS:000687950300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYılmaz, Ülkü
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMonatshefte fur Chemieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPyridine salten_US
dc.subjectXanthine oxidaseen_US
dc.subjectMolecular dockingen_US
dc.subjectCrystal structureen_US
dc.subjectEnzyme inhibitionen_US
dc.titleA study about excellent xanthine oxidase inhibitory effects of new pyridine saltsen_US
dc.typeArticleen_US

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