Effects of aqueous soybean, mistletoe and red clover extracts on activities of adenosine deaminase and xanthine oxidase enzymes

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dc.authoridDevrim, Erdinc/0000-0001-7326-5104|ERGUDER, BERRIN IMGE/0000-0002-7945-3074;
dc.contributor.authorNamuslu, M.
dc.contributor.authorKocaoglu, H.
dc.contributor.authorCelik, H. T.
dc.contributor.authorAvci, A.
dc.contributor.authorDevrim, E.
dc.contributor.authorGenc, Y.
dc.contributor.authorGocmen, E.
dc.date.accessioned2025-10-24T18:09:57Z
dc.date.available2025-10-24T18:09:57Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractSoybean (Glycine max), mistletoe (Viscum album) and red clover (Trifolium pratence) have been argued to have anti-cancer effects. In the present study it was aimed to investigate possible effects of these plant extracts on the activities of DNA turn-over enzymes, namely adenosine deaminase (ADA) and xanthine oxidase (XO) in cancerous and non-cancerous gastric and colon tissues. For this aim, 6 cancerous and 6 non-cancerous adjacent human gastric tissues, and 7 cancerous and 7 non-cancerous adjacent colon tissues were obtained by surgical operations. Our results suggest that aqueous soybean, mistletoe and red clover extracts may exhibit anti-tumoral activity by depleting hypoxanthine concentration in the cancer cells through XO activation, which may lead to lowered salvage pathway activity necessary for the cancer cells to proliferate in the cancerous colon tissue. Some foods like soybean, mistletoe and red clover may provide nutritional support to medical cancer therapy through inhibiting and/or activating key enzymes in cancer metabolism (Tab. 4, Ref. 33). Text in PDF www.elis.sk.
dc.identifier.doi10.4149/BLL_2014_072
dc.identifier.endpage371
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue6
dc.identifier.pmid25023428
dc.identifier.startpage367
dc.identifier.urihttps://doi.org/10.4149/BLL_2014_072
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3898
dc.identifier.volume115
dc.identifier.wosWOS:000339087300009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univ
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectgastric cancer; colon cancer; soybean; mistletoe; red clover; adenosine deaminase; xanthine oxidase
dc.titleEffects of aqueous soybean, mistletoe and red clover extracts on activities of adenosine deaminase and xanthine oxidase enzymes
dc.typeArticle

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