Ultrastructural view of a promising anti TNF-? agent on hepatic ischaemia reperfusion injury

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dc.authoridKilicoglu, Sibel Serin/0000-0002-7658-5186|erdemli, esra/0000-0002-9737-269X
dc.contributor.authorKilicoglu, B.
dc.contributor.authorKilicoglu, S. S.
dc.contributor.authorTuncal, S.
dc.contributor.authorOnalan, A. K.
dc.contributor.authorCelepli, S.
dc.contributor.authorTasova, V
dc.contributor.authorNamuslu, M.
dc.date.accessioned2025-10-24T18:09:57Z
dc.date.available2025-10-24T18:09:57Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBACKGROUND: Ischemia reperfusion causes injury to the liver cells during transplantation, trauma and emergency surgery. We investigated whether the anti TNF-alpha agent, etanercept, can reduce injury in an animal model of ischemia reperfusion owing to the fact that TNF-alpha plays a critical role in the process of inflammation. MATERIALS AND METHODS: Thirty rats were divided into three groups: sham (Group 1), control (Group 2), etanercept (5 mg/kg) treatment (Group 3). Ischemia-reperfusion model was carried out by clamping the hepatic pedicle for 45 min and then reperfusing the liver for 60 min. Etanercept (5 mg/kg) was injected intraperitoneally 5 min prior to reperfusion. At the end of the procedures, blood and liver tissue samples were obtained for biochemical and histopathological assessment. RESULTS: Control and treatment groups showed significant differences in hepatic function tests, plasma and tissue oxidative stress parameters. Samples in the control group histopathologically showed morphologic abnormalities specific to ischemia reperfusion. Histomorphologic findings in the treatment groups showed similar features as the sham group. CONCLUSIONS: Our evidence suggests that TNF-alpha plays a key role in liver ischemia reperfusion injury and etanercept may provide a novel therapeutic approach for patients undergoing liver surgical procedure (Tab. 3, Fig. 4, Ref. 22). Text in PDF www.elis.sk.
dc.identifier.doi10.4149/BLL_2015_117
dc.identifier.endpage607
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue10
dc.identifier.pmid26531871
dc.identifier.scopus2-s2.0-84973367359
dc.identifier.scopusqualityQ2
dc.identifier.startpage601
dc.identifier.urihttps://doi.org/10.4149/BLL_2015_117
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3900
dc.identifier.volume116
dc.identifier.wosWOS:000364353400006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univ
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectliver; ischemia-reperfusion; liver injury; anti TNF-alpha
dc.titleUltrastructural view of a promising anti TNF-? agent on hepatic ischaemia reperfusion injury
dc.typeArticle

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