Epidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year data of Turkish Neonatal Society

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dc.contributor.authorAkin, Ilke Mungan
dc.contributor.authorKanburoglu, Mehmet Kenan
dc.contributor.authorTayman, Cuneyt
dc.contributor.authorOncel, Mehmet Yekta
dc.contributor.authorImdadoglu, Timucin
dc.contributor.authorDilek, Mustafa
dc.contributor.authorKoc, Esin
dc.date.accessioned2026-06-19T06:41:15Z
dc.date.available2026-06-19T06:41:15Z
dc.date.issued2022
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThe literature on neonates with SARS-CoV-2 is mainly concerned with perinatal cases, and scanty data are available about environmentally infected neonates. To fill knowledge gaps on the course and prognosis of neonatal cases, we analyzed 1-year data from the Turkish Neonatal Society in this prospective cohort study of neonates with postnatal transmission. Data from 44 neonatal intensive care units (NICUs), of neonates with positive RT-PCR results at days 5-28 of life, were extracted from the online registry system and analyzed. Of 176 cases, most were term infants with normal birth weight. Fever was the most common symptom (64.2%), followed by feeding intolerance (25.6%), and cough (21.6%). The median length of hospitalization was 9 days, with approximately one quarter of infants receiving some type of ventilatory support. Myocarditis (5.7%) was the most common complication during follow-up. Among the clinical findings, cough (odds ratio [OR]: 9.52, 95% confidence interval [CI]: 4.17-21.71), tachypnea (OR: 26.5, 95% CI: 9.59-73.19), and chest retractions (OR: 27.5, 95% CI: 5.96-126.96) were associated with more severe clinical disease. Also, there were significant differences in the C-reactive protein level, prothrombin time (PT), partial thromboplastin time, international normalized ratio, and days in the NICU (p = 0.002, p = 0.012, p = 0.034, p = 0.008, and p < 0.001, respectively) between patients with mild-moderate and severe-critical presentations. A PT above 14 s was a significant predictor of severe/critical cases, with a sensitivity of 64% and specificity of 73%. Conclusions: Our data showed that late-onset COVID-19 infection in neonates who need hospitalization can be severe, showing associations with high rates of ventilatory support and myocarditis. Cough, tachypnea, and retractions on admission suggest a severe disease course.
dc.identifier.doi10.1007/s00431-021-04358-8
dc.identifier.endpage1942
dc.identifier.issn0340-6199
dc.identifier.issn1432-1076
dc.identifier.issue5
dc.identifier.orcid0000-0003-0760-0773
dc.identifier.orcid0000-0002-3802-0336
dc.identifier.orcid0000-0003-3869-6288
dc.identifier.orcid0000-0002-7550-6765
dc.identifier.orcid0000-0002-3802-0336
dc.identifier.pmid35061093
dc.identifier.scopus2-s2.0-85123408502
dc.identifier.scopusqualityQ1
dc.identifier.startpage1933
dc.identifier.urihttps://doi.org/10.1007/s00431-021-04358-8
dc.identifier.urihttps://hdl.handle.net/20.500.12899/6139
dc.identifier.volume181
dc.identifier.wosWOS:000745396400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEuropean Journal of Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260612
dc.subjectSars-Cov-2
dc.subjectCovid-19
dc.subjectNewborn
dc.subjectPostnatal
dc.titleEpidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year data of Turkish Neonatal Society
dc.typeArticle

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