Association of ambulatory arterial stiffness index with sEPCR in newly diagnosed hypertensive patients

Basit Öğe Kaydı
dc.authoridDarcin, Tahir/0000-0001-5073-1790|Bilgic, Mukadder Ayse/0000-0003-0621-8273
dc.contributor.authorYilmaz, Hakki
dc.contributor.authorCakmak, Muzaffer
dc.contributor.authorInan, Osman
dc.contributor.authorDarcin, Tahir
dc.contributor.authorAktas, Aynur
dc.contributor.authorGurel, Ozgul Malcok
dc.contributor.authorBilgic, Mukadder Ayse
dc.date.accessioned2025-10-24T18:09:44Z
dc.date.available2025-10-24T18:09:44Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAim: Increased arterial stiffness is strongly associated with cardiovascular diseases, while thrombotic events are more common than hemorrhagic events in hypertensive patients. Markers of a hypercoagulable state may also predict future cardiovascular events in hypertensive patients. Here, we speculated that increased arterial stiffness might lead to the development of a hypercoagulable state that can play a role in the thrombotic complications of hypertension. Soluble endothelial protein C receptor (sEPCR) is one such marker of hypercoagulation. The ambulatory arterial stiffness index (AASI) could be accepted as a non-invasive measure of arterial stiffness. The aim of this study was to investigate association of AASI with levels of sEPCR in newly diagnosed hypertensive patients. Materials and methods: The study included 263 newly diagnosed essential hypertensive patients and 55 healthy normotensive controls. All subjects underwent 24 h ambulatory blood pressure monitoring (ABPM); the AASI was derived from ABPM tracings. Plasma sEPCR was measured by ELISA. Results: Hypertensive patients (n=263) had higher AASI, C-reactive protein (CRP) and sEPCR versus the normotensive healthy group (n=55). Univariate analysis showed that AASI was positively associated with age (r=0.212, p< 0.001) body mass index (r=0.412, p<0.001), pulse pressure (r=0.350, p<0.001), plasma sEPCR (r=0.894, p<0.001), 24-h heart rate (r=0.176, p=0.001) and inversely related to high-density lipoprotein (HDL) (r=-0.293, p<0.001). Multivariate analyses revealed that sEPCR and HDL are independently correlated to AASI. Conclusion: We suggest that increased AASI is associated with elevated sEPCR. It might be responsible for subsequent thrombotic events in newly diagnosed hypertensive patients.
dc.identifier.doi10.3109/0886022X.2015.1074472
dc.identifier.endpage1413
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue9
dc.identifier.pmid26335397
dc.identifier.scopus2-s2.0-84944146538
dc.identifier.scopusqualityQ2
dc.identifier.startpage1409
dc.identifier.urihttps://doi.org/10.3109/0886022X.2015.1074472
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3789
dc.identifier.volume37
dc.identifier.wosWOS:000369740900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectAmbulatory arterial stiffness index; arterial stiffness; hypertension; thrombosis; sEPCR
dc.titleAssociation of ambulatory arterial stiffness index with sEPCR in newly diagnosed hypertensive patients
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu