Invasive pneumococci before the introduction of pneumococcal conjugate vaccine in Turkey: antimicrobial susceptibility, serotype distribution, and molecular identification of macrolide resistance

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dc.authoridGur, Deniz/0000-0002-7504-8450|Koseoglu Eser, Ozgen/0000-0002-2552-7971
dc.contributor.authorAltun, Hatice Uludag
dc.contributor.authorHascelik, Gulsen
dc.contributor.authorGur, Deniz
dc.contributor.authorEser, Ozgen Koseoglu
dc.date.accessioned2025-10-24T18:09:33Z
dc.date.available2025-10-24T18:09:33Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThis study evaluates the antimicrobial susceptibilities and serotype distributions of invasive Streptococcus pneumoniae (SP) isolates identified in a Turkish hospital before the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7). The susceptibilities of all isolates were determined by evaluating six antibiotics: penicillin (PEN), ceftriaxone (CRO), levofloxacin (LEV), erythromycin (ERY), clindamycin (CD), and vancomycin (VAN). Serotyping and amplification of macrolide resistance genes were performed. Sixteen (50%) and four (2%) isolates were resistant to PEN and LEV, respectively. No isolates demonstrated VAN resistance. Intermediate resistance to CRO was found in 4% of all invasive isolates. Twenty-three (12.6%) isolates were resistant to ERY. Four (2%) invasive SP isolates demonstrated multidrug resistance. Serogroups 3, 5, 6, 8, 9, and 23 were the most common in both age groups. The potential coverage rates of PCV7 and PCV13 were 44.1 and 66.1% in children and 39.8 and 71.5% in adults, respectively. Continuous surveillance of antimicrobial resistance is required.
dc.description.sponsorshipHacettepe University Scientific Research Unit [08D12101002]
dc.description.sponsorshipThis study was supported by the Hacettepe University Scientific Research Unit with one supportive grant project (Project no: 08D12101002).
dc.identifier.doi10.1179/1973947814Y.0000000176
dc.identifier.endpage79
dc.identifier.issn1120-009X
dc.identifier.issn1973-9478
dc.identifier.issue2
dc.identifier.pmid24548097
dc.identifier.scopus2-s2.0-84923526124
dc.identifier.scopusqualityQ3
dc.identifier.startpage74
dc.identifier.urihttps://doi.org/10.1179/1973947814Y.0000000176
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3694
dc.identifier.volume27
dc.identifier.wosWOS:000351060700003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal Of Chemotherapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectAntimicrobial resistance; PCV7; PCV13; PCR; Serotype; Streptococcus pneumoniae
dc.titleInvasive pneumococci before the introduction of pneumococcal conjugate vaccine in Turkey: antimicrobial susceptibility, serotype distribution, and molecular identification of macrolide resistance
dc.typeArticle

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