Can neutrophil-lymphocyte ratio be independent risk factor for predicting acute kidney injury in patients with severe sepsis?

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dc.authoridDarcin, Tahir/0000-0001-5073-1790;
dc.contributor.authorYilmaz, Hakki
dc.contributor.authorCakmak, Muzaffer
dc.contributor.authorInan, Osman
dc.contributor.authorDarcin, Tahir
dc.contributor.authorAkcay, Ali
dc.date.accessioned2025-10-24T18:09:44Z
dc.date.available2025-10-24T18:09:44Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAim: Neutrophil-lymphocyte ratio (NLR) is an easily calculated, sensitive, and accurate marker for prognosis and diagnosing sepsis, cardiovascular disease and cancer. As sepsis and septic shock are main causes of acute kidney injury (AKI) intensive care unit (ICU), we investigated whether NLR is an early predictor of AKI in patients with severe sepsis. We compared NLR's predictive power with that of other inflammation-related variables. Methods: Between December 2011 and November 2013, we enrolled 118 consecutive cases with severe sepsis admitted to ICU in this retrospective study. Levels of C-reactive protein (CRP), NLR, and white blood cell count (WBC) were recorded on admission and patients' renal function was monitored for seven consecutive days. Results: The rate of AKI occurrence 7 days after enrollment was 57.6%. NLR levels were higher in the AKI group (Group 1) than in the non-AKI group (Group 2) on the day of ICU admission (p<0.001). AKI development was independently associated with NLR, Acute Physiology and Chronic Health Evaluation II (APACHE II) and duration of invasive mechanical ventilation (MV) in multivariate logistic regression analysis. The area under the receiver-operating characteristic (ROC) curve of NLR for predicting AKI was 0.986, which was superior to WBC and CRP (p<0.05). The cut-off value of 10.15 for NLR had the highest validity for predicting AKI in patients with severe sepsis. The sensitivity, specificity, negative-predictive value (NPV), and positive-predictive value (PPV), for this cut-off value was 90.2%, 92.9%, 90.4%, and 92.7%, respectively. Conclusion: NLR is superior to CRP, and WBC for predicting the development of AKI in patients with severe sepsis.
dc.identifier.doi10.3109/0886022X.2014.982477
dc.identifier.endpage229
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue2
dc.identifier.pmid25394529
dc.identifier.scopus2-s2.0-84923209337
dc.identifier.scopusqualityQ2
dc.identifier.startpage225
dc.identifier.urihttps://doi.org/10.3109/0886022X.2014.982477
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3788
dc.identifier.volume37
dc.identifier.wosWOS:000350554300009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInforma Healthcare
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectAcute kidney injury; inflammation; neutrophil-lymphocyte ratio (NLR); sepsis; severe sepsis
dc.titleCan neutrophil-lymphocyte ratio be independent risk factor for predicting acute kidney injury in patients with severe sepsis?
dc.typeArticle

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