The effects of IL-18BP on mRNA expression of inflammatory cytokines and apoptotic genes in renal injury induced by infrarenal aortic occlusion

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dc.contributor.authorGonul, Yucel
dc.contributor.authorGenc, Abdurrahman
dc.contributor.authorAhsen, Ahmet
dc.contributor.authorBal, Ahmet
dc.contributor.authorHazman, Omer
dc.contributor.authorToktas, Muhsin
dc.contributor.authorUlu, M. Sena
dc.date.accessioned2025-10-24T18:09:05Z
dc.date.available2025-10-24T18:09:05Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description24th International Symposium on Morphological Sciences -- SEP 02-06, 2015 -- Istanbul, TURKEY
dc.description.abstractBackground: Renal injury is an important complication of infrarenal aortic occlusion (IAO), which is mainly encountered during the postoperative period. Aortic clamping procedure may lead to turbulent blood flow and eventually vasoconstriction at renal arterial level of the abdominal aorta. IL-18BP has well-known antioxidant and anti-inflammatory properties. In this study, we aimed to determine whether IL-18BP has anti-inflammatory, antiapoptotic, antioxidant, and protective effects on acute kidney damage induced by IAO rat model. Materials and methods: A total of 30 adult male Wistar-Albino rats were equally and randomly separated to three groups as follows: SHAM laparotomy, ischemia-reperfusion (IR), and IR + IL-18BP. We applied 30-min IAO and 2-h reperfusion. Inflammatory cytokine levels (TNF-alpha, IL-1 beta, IL-18, IL-6, and IFN-gamma) and oxidative stress parameters (TAS, TOS, and OSI) were measured. In addition to this, urea and creatinine levels, histopathology of kidney, mRNA expression levels of inflammatory cytokines, and apoptotic genes were investigated. Results: Urea and creatinine, tissue and serum levels of TNF-alpha, IL-6, IL-18, IFN-gamma, and TOS, and oxidative stress index (OSI) were found significantly lower in IR + IL-18BP group, when compared to the IR group. Moreover, mRNA expression levels of inflammatory cytokines and apoptotic genes were prominently depressed in IR + IL-18BP pre-treatment group in histopathologic examination, there was a significant difference between the IR and other three groups (P < 0.001). These improvements were demonstrated with a total score of histopathologic damage. In our previous studies, we have demonstrated that IL-18BP has antioxidant, inflammatory, and protective effects on liver and spinal cord IR injury. Data established from the present study suggest that IL-18BP may exert anti-inflammatory, antiapoptotic, antioxidant, and protective effects on IAO-induced acute kidney injury in rats, and this would be the first study to be conducted in this field. Conclusions: Data established from the present study suggest that IL-18BP may exert anti-inflammatory, antiapoptotic, antioxidant, and protective effects on IAO-induced acute kidney injury in rats. (C) 2016 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.jss.2015.12.026
dc.identifier.endpage42
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue1
dc.identifier.pmid27083945
dc.identifier.scopus2-s2.0-84960968000
dc.identifier.scopusqualityQ1
dc.identifier.startpage33
dc.identifier.urihttps://doi.org/10.1016/j.jss.2015.12.026
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3462
dc.identifier.volume202
dc.identifier.wosWOS:000374969800005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofJournal Of Surgical Research
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectIL-18BP; Infrarenal aortic occlusion; Renal injury; Inflammation; Apoptosis; Oxidative stress
dc.titleThe effects of IL-18BP on mRNA expression of inflammatory cytokines and apoptotic genes in renal injury induced by infrarenal aortic occlusion
dc.typeConference Object

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