An Experimental Insight Into the Role of Agomelatine in Renal Ischemia/Reperfusion Injury

Basit Öğe Kaydı
dc.authoridAltay Ozturk, Dilara/0000-0003-1126-7416
dc.contributor.authorAykora, Damla
dc.contributor.authorBahar, Mehmet Refik
dc.contributor.authorTanbek, Kevser
dc.contributor.authorOzturk, Dilara Altay
dc.contributor.authorKaraca, Elif
dc.contributor.authorSandal, Suleyman
dc.contributor.authorTekin, Suat
dc.date.accessioned2025-10-24T18:08:47Z
dc.date.available2025-10-24T18:08:47Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAcute kidney injury (AKI) is one of the leading causes of chronic kidney disease and accounts for 50%-75% of mortality following renal pathologies or organ transplantation. Ischemia-reperfusion injury (IRI) involves an interrupted blood supply to organs and the kidney; IRI exacerbates AKI development. Owing to several pharmacological treatment methods, AKI still has a poor prognosis, and novel therapeutic options are needed. Agomelatine (AGM) is a melatonin receptor agonist (MT1 and MT2) with increased bioavailability and lipophilicity. In this study, we aimed to investigate the antioxidant and anti-inflammatory effects of AGM in experimental renal IRI via long-term and short-term applications. Sixty male Sprague-Dawley rats were randomly divided into six groups (n = 10): the control, I/R, AGM20S, AGM40S, AGM20L, and AGM40L groups. Following the establishment of the renal IRI model, the rats received agomelatine at 20 and 40 mg/kg orally, and agomelatine solvent (hydroxyethylcellulose) was used as a vehicle. At the end of the experiment, blood samples and renal tissues were harvested for histopathological and biochemical analysis. Urea, creatinine, tumor necrosis factor (TNF-alpha), and interleukin-1 beta (IL-1 beta) levels were measured in blood serum samples. Malondialdehyde (MDA) levels and increased superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), and total glutathione (GSH) levels were measured in renal tissue supernatants. Our biochemical results indicated that AGM reduced creatinine, TNF-alpha, IL-1 beta, and malondialdehyde levels and increased SOD, CAT, GSHPx, and total GSH levels. Agolematine reduced infiltration, intratubular hemorrhage, and intratubular cast formation histopathologically. Our results suggest that AGM could be a potential therapeutic adjuvant agent for ischemia-reperfusion injury in the kidney and several other organs.
dc.description.sponsorshipInonu University, Scientific Research Projects Coordination Unit [TYL/2019-1762]
dc.description.sponsorshipThis study was funded by Inonu University, Scientific Research Projects Coordination Unit, with TYL/2019-1762 project number.
dc.identifier.doi10.1002/jbt.70090
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue12
dc.identifier.pmid39655682
dc.identifier.urihttps://doi.org/10.1002/jbt.70090
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3284
dc.identifier.volume38
dc.identifier.wosWOS:001372809000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal Of Biochemical And Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectagomelatine; ischemia; oxidative stress; reactive oxygen species; reperfusion
dc.titleAn Experimental Insight Into the Role of Agomelatine in Renal Ischemia/Reperfusion Injury
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu