Morinda citrifolia protective effects on paclitaxel-induced testis parenchyma toxicity: An experimental study

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dc.contributor.authorGenc, Sidika
dc.contributor.authorCicek, Betul
dc.contributor.authorYeni, Yesim
dc.contributor.authorKuzucu, Mehmet
dc.contributor.authorHacimuftuoglu, Ahmet
dc.contributor.authorBolat, Ismail
dc.contributor.authorTaghizadehghalehjoughi, Ali
dc.date.accessioned2026-06-19T06:39:44Z
dc.date.available2026-06-19T06:39:44Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThe current study aimed to investigate the sensitivity of male testis parenchyma cells to chemotherapy agents and the protective effects and mechanisms of Morinda citrifolia (Noni) administration against structural and functional changes before and after chemotherapy (Paclitaxel (PTX)). For this purpose, rats were randomly assigned into four groups (Control = G1, PTX 5 mg/kg = G2; PTX + Noni 10 mg/kg = G3, PTX + Noni 20 mg/kg = G4). PTX was injected intraperitoneally for 4 consecutive weeks, at a dose of 5 mg/kg to all groups except the control group. Then noni was administrated in 10 (G3) and 20 (G4) mg/kg groups orally (gavage) for 14 days. Biochemical analyses, Real-Time Polymerase Chain Reaction (PCR), and immunohistochemical analyses were performed. According to our results, Total Oxidative Stress (TOS) and Malondialdehyde (MDA) were significantly increased in the PTX group (P < 0.01). Superoxide Dismutase (SOD) enzyme activity and Total Antioxidant Capacity (TAC) levels were decreased (P < 0.01). The changes in the rats treated with PTX + Noni 20 mg/ kg were noteworthy. The increased levels of IL1-beta (Interleukin 1 beta) and TNF alpha (tumor necrosis factor-alpha) with PTX were down-regulated after treatment with PTX + Noni 20 mg/kg (P < 0.01) (9 % and 5 % respectively). In addition, Noni restored the testicular histopathological structure by reducing caspase-3 expression and significantly (61 %) suppressed oxidative DNA damage and apoptosis (by regulating the Bax (bcl-2-like protein 4)/Bcl-2 (B-cell lymphoma gene-2) ratio). In conclusion, Noni reduced cellular apoptosis and drastically changed Caspase 8 and Bax/Bcl-2 levels. Furthermore, it considerably decreases oxidative damage and can be used in testicular degeneration.
dc.identifier.doi10.1016/j.reprotox.2024.108611
dc.identifier.issn0890-6238
dc.identifier.issn1873-1708
dc.identifier.orcid0000-0002-5287-4450
dc.identifier.orcid0000-0003-3824-2462
dc.identifier.pmid38782144
dc.identifier.scopus2-s2.0-85194370103
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.reprotox.2024.108611
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5744
dc.identifier.volume127
dc.identifier.wosWOS:001249219200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofReproductive Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260612
dc.subjectTestis Parenchyma Cells
dc.subjectNoni Administration
dc.subjectOxidative Stress And Antioxidant Levels
dc.subjectBax
dc.subjectBcl-2
dc.subjectPaclitaxel
dc.titleMorinda citrifolia protective effects on paclitaxel-induced testis parenchyma toxicity: An experimental study
dc.typeArticle

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