The effects of low and high doses of sugammadex on kidney tissue in streptozotocin-induced diabetic rats

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dc.authoridArslan, Mustafa/0000-0003-4882-5063|AYDIN, Muhammed Enes/0000-0001-8491-6566
dc.contributor.authorKip, G.
dc.contributor.authorTurgut, H. C.
dc.contributor.authorAlkan, M.
dc.contributor.authorAydin, M. E.
dc.contributor.authorErbatur, M. E.
dc.contributor.authorKiraz, H. A.
dc.contributor.authorKartal, S.
dc.date.accessioned2025-10-24T18:09:57Z
dc.date.available2025-10-24T18:09:57Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBACKGROUND: Sugammadex is primarily excreted via renal route. We investigated effects of low and high doses of sugammadex (16 mg/kg versus 96 mg/kg) on renal tissue samples of streptozotocin-induced diabetic rats. MATERIAL AND METHODS: Twenty-four Wistar albino rats were divided into 4 groups. Group C (control - 0.9 % NaCl), Group DC (diabetes control; 55 mg/kg streptozotocin, IP, only), Group DR-16S (diabetes-rocuronium - 16 mg sugamnnadex, IV.) and Group DR-96S (diabetes- rocuronium - 96 mg sugammadex, IV). Renal tissue histopathological evaluation and antioxidant status (measurements of MDA levels and NO activities) were studied. RESULTS: Significantly higher levels of all inflammation parameters (inflammation, degeneration/necrosis, tubular dilatation, tubular cell degeneration, dilatation in Bowman's space, tubular hyaline casts, and lymphocyte infiltration) were found in the 96 mg/kg sugammadex group. Higher MDA tissue levels and lower NO activity were found in the 96 mg/kg sugammadex group. DISCUSSION: We can conclude that high-dose (96 mg/kg) sugammadex administration resulted in significant renal tissue damage in diabetic rats. As a consequence, low doses of sugamnnadex have to be preferred in diabetic patients (Tab. 2, Fig. 4, Ref. 26). Text in PDF www.elis.sk.
dc.identifier.doi10.4149/BLL_2015_146
dc.identifier.endpage750
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue12
dc.identifier.pmid26924146
dc.identifier.scopus2-s2.0-84973369159
dc.identifier.scopusqualityQ2
dc.identifier.startpage746
dc.identifier.urihttps://doi.org/10.4149/BLL_2015_146
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3901
dc.identifier.volume116
dc.identifier.wosWOS:000367280800011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univ
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectsugammadex; streptozotocin; diabetes; renal damage
dc.titleThe effects of low and high doses of sugammadex on kidney tissue in streptozotocin-induced diabetic rats
dc.typeArticle

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