Clinical significance of ADAMTS1, ADAMTS5, ADAMTS9 aggrecanases and IL-17A, IL-23, IL-33 cytokines in polycystic ovary syndrome

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dc.authoridsahin, mustafa/0000-0002-4718-0083|Demirci, Taner/0000-0002-9579-4530|cakal, erman/0000-0003-4455-7276|Delibasi, Tuncay/0000-0002-5780-8209
dc.contributor.authorKarakose, M.
dc.contributor.authorDemircan, K.
dc.contributor.authorTutal, E.
dc.contributor.authorDemirci, T.
dc.contributor.authorArslan, M. S.
dc.contributor.authorSahin, M.
dc.contributor.authorCelik, H. T.
dc.date.accessioned2025-10-24T18:08:53Z
dc.date.available2025-10-24T18:08:53Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPolycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) are involved in inflammation and fertility. The aim of this investigation was to evaluate the serum levels of ADAMTS1, ADAMTS5, ADAMTS9, IL-17, IL-23, IL-33 and to find out the relationship between these inflammatory cytokines and ADAMTSs in PCOS patients. A case-control study was performed in a training and research hospital. Eighty patients with PCOS and seventy-eight healthy female volunteers were recruited in the present study. Serum ADAMTS and IL levels were determined by a human enzyme-linked immunoassay (ELISA) in all subjects. The IL-17A, IL-23 and IL-33 levels were significantly higher in the PCOS patients compared to the controls (p < 0.05). We could not find significant difference between the groups in terms of ADAMTS1, ADAMTS5 and ADAMTS9 levels. IL-17A had positive correlations with LDL cholesterol and IL-33 and negative correlations with ADAMTS1, ADAMTS5, and ADAMTS9. IL-33 had positive correlation with LDL cholesterol and IL-17A. In ROC curve analysis, PCOS can be predicted by the use of IL-17A, IL-23 and IL-33 which at a cut-off value of 8.37 pg/mL (44 % sensitivity, 83 % specificity), 26.75 pg/mL (36 % sensitivity, 64 % specificity) and 14.28 pg/mL (83 % sensitivity, 39 % specificity), respectively. The results of the study might suggest that ADAMTS and IL molecules have a role in the pathogenesis of the PCOS. Further efforts are needed to establish causality for ADAMTS-IL axis.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [114S039]
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK, Grant Number: 114S039).
dc.identifier.doi10.1007/s40618-016-0472-2
dc.identifier.endpage1275
dc.identifier.issn1720-8386
dc.identifier.issue11
dc.identifier.pmid27146815
dc.identifier.scopus2-s2.0-84991585416
dc.identifier.scopusqualityQ1
dc.identifier.startpage1269
dc.identifier.urihttps://doi.org/10.1007/s40618-016-0472-2
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3363
dc.identifier.volume39
dc.identifier.wosWOS:000386601500007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal Of Endocrinological Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectPolycystic ovary syndrome; ADAMTS; Interleukin; Insulin resistance
dc.titleClinical significance of ADAMTS1, ADAMTS5, ADAMTS9 aggrecanases and IL-17A, IL-23, IL-33 cytokines in polycystic ovary syndrome
dc.typeArticle

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