Is the level of maternal serum prohepcidin associated with preeclampsia?

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dc.authoridBicer, Cemile/0000-0001-7937-4475
dc.contributor.authorDuvan, Candan Iltemir
dc.contributor.authorSimavli, Serap
dc.contributor.authorKeskin, Esra Aktepe
dc.contributor.authorOnaran, Yuksel
dc.contributor.authorTurhan, Nilgun Ozturk
dc.contributor.authorKoca, Cemile
dc.date.accessioned2025-10-24T18:09:44Z
dc.date.available2025-10-24T18:09:44Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: The objective of the study was to compare pro-hepcidin, hemoglobin (Hb) concentration, hematocrit (Hct), C-reactive protein (CRP), IL-6 and iron status parameters in preeclamptic (PE) and healthy pregnant women, and to examine the relationship between serum pro-hepcidin levels and iron parameters of preeclampsia (PE). Methods: In a prospective controlled study, we collected serum from women with normal pregnancy (n = 37) and from women with PE (n = 30) at the Department of Obstetrics and Gynecology at Turgut Ozal University between February 2010 and January 2013. Pro-hepcidin, hemoglobin (Hb) concentration, hematocrit (Hct), CRP, IL-6 and iron status parameters were measured in all patients and compared between groups. Results: Levels of serum prohepcidin in PE and control groups were similar and amount 69.4 +/- 19.7 and 71.9 +/- 22.1 ng/ml, respectively. The difference was not statistically significant (p: 0.694). On the other hand, the study group had a statistically lower iron binding capacity (IBC), total iron binding capacity, transferin, total protein, albumin levels (p<0.05). No significant differences were found among prohepcidin, Hb concentration, Hct, iron, ferritin, IL-6, urea and creatine in both the groups. Conclusion: In pregnancies complicated by PE with normal values of hemoglobin and hematocrit, serum prohepcidin concentrations are similar to those observed in healthy pregnant women. The analysis revealed no significant correlations between prohepcidin level and serum iron, serum ferritin or transferrin in the PE.
dc.identifier.doi10.3109/10641955.2014.988350
dc.identifier.endpage152
dc.identifier.issn1064-1955
dc.identifier.issn1525-6065
dc.identifier.issue2
dc.identifier.pmid25548972
dc.identifier.scopus2-s2.0-84926457675
dc.identifier.scopusqualityQ2
dc.identifier.startpage145
dc.identifier.urihttps://doi.org/10.3109/10641955.2014.988350
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3797
dc.identifier.volume34
dc.identifier.wosWOS:000352549000002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofHypertension In Pregnancy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectFerritin; preeclampsia; prohepcidin; serum iron
dc.titleIs the level of maternal serum prohepcidin associated with preeclampsia?
dc.typeArticle

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