A successful healthy live birth from a female patient with hypogonadotropic hypogonadism and oocytes with unusually large cytoplasmic inclusions

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dc.contributor.authorDuvan, Candan Iltemir
dc.contributor.authorPekel, Aslihan
dc.contributor.authorErcan, Ummu Gulsum
dc.contributor.authorArikan, Yuksel Onaran
dc.date.accessioned2025-10-24T18:10:13Z
dc.date.available2025-10-24T18:10:13Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThis study aimed to report the case of a successful live birth from a woman having oocytes with abnormally large cytoplasmic inclusions. The patient described in this case is a 28 year-old woman with hypogonadotropic hypogonadism (HH) with a history of two previous unsuccessful in vitro fertilization (IVF) attempts offered an antagonist protocol. Stimulation was performed with human menopausal gonadotropin 300 IU/day. The intracytoplasmic sperm injection (ICSI) procedure was performed 4-6 hours after oocyte aspiration for all mature oocytes. Six oocytes were retrieved, five of which mature (MII). All oocytes had abnormal cytoplasmic structures. Two were fertilized after ICSI and two top quality embryos were transferred on Day 2. Our case report suggests that HH patients with refractile bodies/lipofuscin in their oocytes may not have their pregnancies negatively affected. While there have been several reports of successful births from dysmorphic oocytes, no cases of successful pregnancies followed by live births from young women with HH and oocytes with large cytoplasmic inclusions had been reported to date.
dc.identifier.doi10.5935/1518-0557.20160011
dc.identifier.endpage46
dc.identifier.issn1517-5693
dc.identifier.issn1518-0557
dc.identifier.issue1
dc.identifier.pmid27203307
dc.identifier.scopus2-s2.0-84959471936
dc.identifier.scopusqualityQ2
dc.identifier.startpage44
dc.identifier.urihttps://doi.org/10.5935/1518-0557.20160011
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4046
dc.identifier.volume20
dc.identifier.wosWOS:000405249100011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSoc Brasileira Reproducao Assistida-Sbra
dc.relation.ispartofJornal Brasileiro De Reproducao Assistida
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectRefractile body; Lipofuscin; Oocyte Cytoplasm; ICSI
dc.titleA successful healthy live birth from a female patient with hypogonadotropic hypogonadism and oocytes with unusually large cytoplasmic inclusions
dc.typeArticle

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